Luliconazole-loaded nanostructured lipid carriers for topical treatment of superficial Tinea infections

被引：37

作者：

Baghel, Saahil ^{[1
]}

Nair, Vishnumaya S. ^{[1
]}

Pirani, Asma ^{[1
]}

Sravani, Anne Boyina ^{[1
]}

Bhemisetty, Brahmam ^{[1
]}

Ananthamurthy, Koteshwara ^{[2
]}

Aranjani, Jesil Mathew ^{[2
]}

Lewis, Shaila A. ^{[1
]}

机构：

[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal 576104, Karnataka, India

[2] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut Biotechnol, Manipal, Karnataka, India

来源：

DERMATOLOGIC THERAPY | 2020年 / 33卷 / 06期

关键词：

antifungal; bioavailability; dermatophytosis; luliconazole; nanostructured lipid carriers; Tinea; topical delivery; IN-VITRO; DELIVERY; NANOPARTICLES; GEL; FORMULATION; NANOCRYSTALS; INFLAMMATION; FLUCONAZOLE; DESIGN; NLC;

D O I：

10.1111/dth.13959

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Tinea are superficial fungal infections caused by dermatophytes. Luliconazole exhibits highest antifungal activity againstTrichophytonspp. which are major causative agents of dermatophytosis.However, luliconazole suffers from drawbacks such as less skin retention, low aqueous solubility and poor skin penetration. To overcome the limitations of luliconazole, nanostructured lipid carriers (NLCs) were formulated. NLCs are better permeation enhancers as they increase skin occlusion and hydration. The selection of various lipids and surfactants was based on the solubility of luliconazole in these components. Luliconazole NLC dispersion was prepared by hot melt emulsification technique followed by probe sonication. The dispersion was incorporated into a gel composed of Sepineo P 600 under magnetic stirring. in vitro antifungal studies were carried out with optimized luliconazole NLC gel, marketed luliconazole cream and control (luliconazole in gel base) against pathogenicTrichophyton rubrum. Ex-vivo diffusion study demonstrated that NLCs incorporated into gel exhibited greater retention on skin. In-vivo skin irritancy study showed no signs of erythema or edema post 24, 48, and 72 h at site of application. In comparison with marketed cream and based on the zone of inhibition diameters, NLC formulation was found to be very effective againstTrichophyton rubrum.

引用

页数：12

共 40 条

[1] Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis [J].