Ancestral hemoglobins in Archaea

被引：89

作者：

Freitas, TAK

Hou, SB

Dioum, EM

Saito, JA

Newhouse, J

Gonzalez, G

Gilles-Gonzalez, MA

Alam, M

机构：

[1] Univ Hawaii Manoa, Dept Microbiol, Honolulu, HI 96822 USA

[2] Maui High Performance Comp Ctr, Maui, HI 96753 USA

[3] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 17期

关键词：

globin-coupled sensor; oxygen sensor; NO sensor; myoglobin;

D O I：

10.1073/pnas.0308657101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hemoglobins are ubiquitous in Eukarya and Bacteria but, until now, have not been found in Archaea. A phylogenetic analysis of the recently revealed microbial family of globin-coupled heme-based sensors suggests that these sensors descended from an ancient globin-only progenitor, or a protoglobin (Pgb). Here, we report the discovery and characterization of two Pgbs from the Archaea: ApPgb from the obligately aerobic hyperthermophile Aeropyrum pernix, and MaPgb from the strictly anaerobic methanogen Methanosarcina acetivorans. Both ApPgb and MaPgb bind molecular oxygen, nitric oxide, and carbon monoxide by means of a heme moiety that is coordinated to the protein through the F8 histidine (histidine 120). We postulate that these archaeal globins are the ancestors of contemporary hemoglobins.

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收藏

页码：6675 / 6680

页数：6

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