Early Preinvasive Lesions in Ovarian Cancer

被引:19
作者
Chene, Gautier [1 ]
Lamblin, Gery [1 ]
Le Bail-Carval, Karine [1 ]
Chabert, Philippe [1 ]
Bakrin, Naoual [1 ]
Mellier, Georges [1 ]
机构
[1] Univ Hosp Lyon, Hop Femme Mere Enfant, Dept Gynecol, F-69000 Lyon, France
关键词
TUBAL INTRAEPITHELIAL CARCINOMA; PROPHYLACTIC OOPHORECTOMY SPECIMENS; HOSPITAL DISCHARGE DIAGNOSIS; SEROUS BORDERLINE TUMORS; FALLOPIAN-TUBE; SURFACE EPITHELIUM; CLEAR-CELL; EARLY EVENTS; PATHOLOGICAL FINDINGS; INCESSANT OVULATION;
D O I
10.1155/2014/639252
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Faced with the catastrophic prognosis for ovarian cancer due to the fact that it is most often diagnosed late at the peritoneal carcinomatosis stage, screening and early detection could probably reduce the mortality rate. A better understanding of the molecular characteristics of the different ovarian cancer subtypes and their specific molecular signatures is indispensable prior to development of new screening strategies. We discuss here the early natural history of ovarian cancer and its origins.
引用
收藏
页数:11
相关论文
共 122 条
[1]   Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation [J].
An, HX ;
Beckmann, MW ;
Reifenberger, G ;
Bender, HG ;
Niederacher, D .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (01) :113-118
[2]  
[Anonymous], 2010, J ONCOL
[3]   Early events in ovarian epithelial carcinogenesis: progress and problems in experimental approaches [J].
Auersperg, N ;
Ota, T ;
Mitchell, GWE .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2002, 12 (06) :691-703
[4]  
AUERSPERG N, 1994, LAB INVEST, V71, P510
[5]   The Stem-Cell Profile of Ovarian Surface Epithelium is Reproduced in the Oviductal Fimbriae, with Increased Stem-Cell Marker Density in Distal Parts of the Fimbriae [J].
Auersperg, Nelly .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2013, 32 (05) :444-453
[6]   Ovarian surface epithelium as a source of ovarian cancers: Unwarranted speculation or evidence-based hypothesis? [J].
Auersperg, Nelly .
GYNECOLOGIC ONCOLOGY, 2013, 130 (01) :246-251
[7]  
Auersperg Nelly, 2013, Front Biosci (Schol Ed), V5, P709
[8]  
BERCHUCK A, 1993, CANCER, V71, P545
[9]   Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis [J].
Borgfeldt, C ;
Andolf, E .
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2004, 83 (04) :395-400
[10]   Cancer risk after a hospital discharge diagnosis of endometriosis [J].
Brinton, LA ;
Gridley, G ;
Persson, I ;
Baron, J ;
Bergqvist, A .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1997, 176 (03) :572-579