Equine arteritis virus

被引：74
作者：
Balasuriya, Udeni B. R. [1 ]
Go, Yun Young [1 ]
MacLachlan, N. James [2 ]
机构：
[1] Univ Kentucky, Gluck Equine Res Ctr, Dept Vet Sci, Lexington, KY 40546 USA
[2] Univ Calif Davis, Sch Vet Med, Dept Pathol Microbiol & Immunol, Davis, CA 95616 USA
来源：
VETERINARY MICROBIOLOGY | 2013年 / 167卷 / 1-2期
基金：
美国食品与农业研究所;
关键词：
Equine arteritis virus; EAV; EVA; RESPIRATORY SYNDROME VIRUS; POLYMERASE-CHAIN-REACTION; MAJOR ENVELOPE PROTEINS; MESSENGER-RNA SYNTHESIS; INFECTIOUS CDNA-CLONE; MORPHOLINO ANTISENSE OLIGOMERS; LINKED-IMMUNOSORBENT-ASSAY; GENOME-WIDE ASSOCIATION; REPLICASE ORF1A PROTEIN; INNATE IMMUNE-RESPONSE;
D O I：
10.1016/j.vetmic.2013.06.015
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies. (C) 2013 Elsevier B.V. All rights reserved.
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收藏
页码：93 / 122
页数：30
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