Synthesis of 3-Carbamoyl β-Lactams via Manganese(III)-Promoted Cyclization of N-Alkenylmalonamides

被引：4

作者：

Punda, Pawel ^{[1
]}

Ponikiewski, Lukasz ^{[1
]}

Makowiec, Slawomir ^{[1
]}

机构：

[1] Gdansk Univ Technol, Fac Chem, Dept Organ Chem, PL-80952 Gdansk, Poland

来源：

HELVETICA CHIMICA ACTA | 2013年 / 96卷 / 11期

关键词：

Cyclization reactions; Manganese(III) acetate; Lactams; Malonamides; N-alkenyl-; RADICAL CYCLIZATION; ENAMIDES;

D O I：

10.1002/hlca.201200646

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Manganese(III)-promoted cyclization of N-alkenylmalonamides (=N-alkenylpropanediamides) gave 3-(aryl/(alkylamino)carbonyl) -lactams as well as 3-(aryl/(alkylamino)thiocarbonyl) -lactams. The relative configuration of the obtained products was unambiguously determined by X-ray crystallography. The proposed method is very useful for the one-pot synthesis of a number of 3-(aryl/(alkylamino)carbonyl) -lactams, especially those containing an amino(thiocarbonyl) moiety, which are not selectively accessible by other methods.

引用

页码：2081 / 2091

页数：11

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