The skin surface as antimicrobial barrier: present concepts and future outlooks

被引：94

作者：

Harder, Juergen ^{[1
]}

Schroeder, Jens-Michael ^{[1
]}

Glaeser, Regine ^{[1
]}

机构：

[1] Univ Hosp Schleswig Holstein, Dept Dermatol, Campus Kiel,Schittenhelmstr 7, D-24105 Kiel, Germany

来源：

EXPERIMENTAL DERMATOLOGY | 2013年 / 22卷 / 01期

关键词：

antimicrobial proteins; cutaneous defense; STAPHYLOCOCCUS-AUREUS INFECTION; HUMAN EPIDERMAL-KERATINOCYTES; INNATE IMMUNE-RESPONSE; ATOPIC-DERMATITIS; RNASE; 7; HUMAN BETA-DEFENSIN-2; ENHANCED EXPRESSION; ESCHERICHIA-COLI; PSORIASIN S100A7; METAZOAN HYDRA;

D O I：

10.1111/exd.12046

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Human skin protects the body as an outer barrier from various environmental threats and has to deal with an immense quantity of microbes comprising members of the own microbiota as well as potential pathogenic microbes. In this viewpoint, we highlight important cutaneous first-line defense barriers from the perspective of a microbe that tries to colonize and invade human skin. We place special emphasis on the role of antimicrobial peptides and the microbiota. In addition, we discuss and try to provide answers to some emerging issues concerning the various defense strategies of the epidermis.

引用

页码：1 / 5

页数：5

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