Chiral 1,3,2-Diazaphospholenes as Catalytic Molecular Hydrides for Enantioselective Conjugate Reductions

被引：52

作者：

Miaskiewicz, Solene ^{[1
]}

Reed, John H. ^{[1
]}

Donets, Pavel A. ^{[1
]}

Oliveira, Caio C. ^{[1
]}

Cramer, Nicolai ^{[1
]}

机构：

[1] EPFL SB ISIC LCSA, Lab Asymmetr Catalysis & Synth, BCH 4305, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 15期

基金：

瑞士国家科学基金会;

关键词：

asymmetric catalysis; diazaphospholenes; organocatalysis; phosphorus; reduction; N-HETEROCYCLIC PHOSPHINES; ASYMMETRIC HYDROGENATION; CARBENE LIGANDS; HYDROBORATION; ESTERS; BOND;

D O I：

10.1002/anie.201801300

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Secondary 1,3,2-diazaphospholenes have a polarized P-H bond and are emerging as molecular hydrides. Herein, a class of chiral, conformationally restricted methoxy-1,3,2-diazaphospholene catalysts is reported. We demonstrate their catalytic potential in asymmetric 1,4-reductions of ,-unsaturated carbonyl derivatives, including enones, acyl pyrroles, and amides, which proceeded in enantioselectivities of up to 95.5:4.5 e.r.

引用

页码：4039 / 4042

页数：4

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