Neuropeptidase activity is down-regulated by estradiol in steroid-sensitive regions of the hypothalamus in female mice

被引：9

作者：

Bruce, Lisa A. ^{[1
]}

Cyr, Nicole E. ^{[1
]}

Qiao, Jana W. ^{[1
]}

DeFries, Christa C. ^{[1
]}

Tetel, Marc J. ^{[2
]}

Wolfson, Adele J. ^{[1
]}

机构：

[1] Wellesley Coll, Dept Chem, Wellesley, MA 01746 USA

[2] Wellesley Coll, Neurosci Program, Wellesley, MA 02181 USA

来源：

NEUROPEPTIDES | 2012年 / 46卷 / 04期

基金：

美国国家科学基金会;

关键词：

Thimet oligopeptidase; Estradiol; Hypothalamus; GnRH; Prolyl endopeptidase; Ventromedial nucleus; ENDOPEPTIDASE EC 3.4.24.15; PROLYL OLIGOPEPTIDASE; RAT-BRAIN; THIMET OLIGOPEPTIDASE; SUBCELLULAR-DISTRIBUTION; HORMONE NEURONS; DIRECT INPUT; METALLOENDOPEPTIDASE; EC-3.4.24.15; EWE;

D O I：

10.1016/j.npep.2012.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thimet oligopeptidase (TOP) and prolyl endopeptidase (PEP) are neuropeptidases involved in the hydrolysis of gonadotropin-releasing hormone, a key component of the hypothalamic-pituitary-gonadal axis. GnRH is regulated in part by feedback from steroid hormones such as estradiol. Previously, we demonstrated that TOP levels are down-regulated by estradiol in reproductively-relevant regions of the female rodent brain. The present study supports these findings by showing that TOP enzyme activity, as well as protein levels, in the ventromedial hypothalamic nucleus of female mice is controlled by estradiol. We further demonstrate that PEP levels in this same brain region are down-regulated by estradiol in parallel with those of TOP. These findings provide evidence that these neuropeptidases are part of the fine control of hormone levels in the HPG axis. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：167 / 172

页数：6

共 30 条

[1] EFFECTS OF MEMANTINE ON SOLUBLE Aβ25-35-INDUCED CHANGES IN PEPTIDERGIC AND GLIAL CELLS IN ALZHEIMER'S DISEASE MODEL RAT BRAIN REGIONS [J].