PAX3 and PAX7 as upstream regulators of myogenesis

被引:177
作者
Buckingham, Margaret [1 ]
Relaix, Frederic [2 ,3 ,4 ,5 ]
机构
[1] Inst Pasteur, CNRS, URA 2578, Dept Dev & Stem Cell Biol, F-75015 Paris, France
[2] INSERM, U955, IMRB, Team 10, F-94000 Creteil, France
[3] UPEC Paris Est Creteil Univ, Fac Med, F-94000 Creteil, France
[4] Etab Francais Sang, F-94017 Creteil, France
[5] Univ Paris Est, Ecole Natl Vet Alfort, F-94700 Maisons Alfort, France
关键词
Pax3; Pax7; Myogenesis; Muscle stem cells; MUSCLE PROGENITOR CELLS; DNA-BINDING ACTIVITY; SKELETAL-MUSCLE; SATELLITE CELLS; NEURAL CREST; STEM-CELL; SELF-RENEWAL; PRECURSOR CELLS; TRANSCRIPTIONAL ACTIVITY; MAINTAIN QUIESCENCE;
D O I
10.1016/j.semcdb.2015.09.017
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play important roles in the emergence of a number of different tissues during development. PAX3 regulates neural crest and, together with its orthologue PAX7, is also expressed in parts of the central nervous system. In this chapter we will focus on their role in skeletal muscle. Both factors are key regulators of myogenesis where Pax3 plays a major role during early skeletal muscle formation in the embryo while Pax7 predominates during post-natal growth and muscle regeneration in the adult. We review the expression and functions of these factors in the myogenic context. We also discuss mechanistic aspects of PAX3/7 function and modulation of their activity by interaction with other proteins, as well as the post-transcriptional and transcriptional regulation of their expression. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:115 / 125
页数:11
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