Self-assembly of DNA double multi-arm junctions (DMaJs']Js)

被引：5

作者：

Li, Mo ^{[1
]}

Yu, Jinwen ^{[1
]}

Li, Jingtong ^{[2
]}

Ben Wang, Eric ^{[1
]}

Wang, Guansong ^{[2
]}

Mao, Chengde ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[2] Xingiao Hosp, Inst Resp Dis, Chongqing 400037, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 80期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1039/c6ra15145k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This article develops a class of DNA nanomotifs: double multi-arm junction (DMaJ) nanomotifs or tiles. Each motif consists of two multi-arm, branched, DNA junctions (either 6- or 8-arm-junctions). In the DMaJ motifs, two, long, parallel, DNA duplexes allow the tiles to interact with each other to form large nanostructure frameworks. In addition, they contain extra helical domains that could provide easy anchors for additional functional/structural elements or opportunities for complex, inter-motif connectivity to construct complex DNA-based nanomaterials. We have thoroughly characterized the formation of the new motifs by polyacrylamide gel electrophoresis (PAGE) and their assembly behaviors by atomic force microscopy (AFM) imaging.

引用

页码：76355 / 76359

页数：5

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