FGF21 mediates the lipid metabolism response to amino acid starvation

被引：99
作者：
De Sousa-Coelho, Ana Luisa [1 ,2 ]
Relat, Joana [1 ,2 ]
Hondares, Elayne [2 ,3 ,4 ]
Perez-Marti, Albert [1 ,2 ]
Ribas, Francesc [2 ,3 ,4 ]
Villarroya, Francesc [2 ,3 ,4 ]
Marrero, Pedro F. [1 ,2 ]
Haro, Diego [1 ,2 ]
机构：
[1] Univ Barcelona, Dept Bioquim & Biol Mol, Fac Farm, E-08028 Barcelona, Spain
[2] Univ Barcelona IBUB, Inst Biomed, Barcelona 08028, Spain
[3] Univ Barcelona, Dept Bioquim & Biol Mol, Fac Biol, E-08028 Barcelona, Spain
[4] CIBER Fisiopatol Obesidad & Nutr, Barcelona 08028, Spain
来源：
JOURNAL OF LIPID RESEARCH | 2013年 / 54卷 / 07期
关键词：
brown adipose tissue; fibroblast growth factor 21; leucine deprivation; liver; white adipose tissue; GROWTH-FACTOR; 21; ACTIVATED-RECEPTOR-GAMMA; PPAR-ALPHA; ADIPOSE-TISSUE; HEPATIC FGF21; BROWN FAT; EXPRESSION; CELLS; LIVER; FIBROBLAST-GROWTH-FACTOR-21;
D O I：
10.1194/jlr.M033415
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21-deficient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation.
引用
收藏
页码：1786 / 1797
页数：12
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