Role of T cell immunity in hepatitis C virus infections

被引：31

作者：

Claassen, Mark A. A. ^{[1
,2
]}

Janssen, Harry L. A. ^{[1
,3
]}

Boonstra, Andre ^{[1
]}

机构：

[1] Univ Med Ctr Rotterdam, Erasmus MC, Dept Gastroenterol & Hepatol, Liver Unit, Rotterdam, Netherlands

[2] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Infect Dis Unit, Rotterdam, Netherlands

[3] Univ Toronto, Div Gastroenterol, Liver Clin Univ Hlth Network, Toronto, ON M5S 1A1, Canada

来源：

CURRENT OPINION IN VIROLOGY | 2013年 / 3卷 / 04期

关键词：

GROWTH-FACTOR-BETA; IFN-ALPHA-BETA; PD-1; EXPRESSION; FUNCTIONAL RESTORATION; VIRAL PERSISTENCE; LIVER-DISEASE; TH17; CELLS; B-VIRUS; RESPONSES; CD4(+);

D O I：

10.1016/j.coviro.2013.05.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic infections with the hepatitis C virus (HCV) are a major global health issue. Viral replication is restricted to hepatocytes, and occurs for decades at high replication rates. Over the last decade, it became accepted that HCV-specific CD4(+) and CD8(+) T cells are crucial for protective immunity to HCV. However, a characteristic feature of persistent HCV infection is the dysfunctional T cell response, and over recent years enormous progress has been made in understanding the mechanisms that dampen the antiviral T cell responses in blood and liver of chronic HCV patients and also impact disease progression.

引用

页码：461 / 467

页数：7

共 67 条

[11] Increased hepatitis C virus (HCV)-specific CD4+CD25 + regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels [J].

Bolacchi, F ;

Sinistro, A ;

Ciaprini, C ;

Demin, F ;

Capozzi, M ;

Carducci, FC ;

Drapeau, CMJ ;

Rocchi, G ;

Bergamini, A .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2006, 144 (02) :188-196

[12] Adaptive immune responses in acute and chronic hepatitis C virus infection [J].

Bowen, DG ;

Walker, CM .

NATURE, 2005, 436 (7053) :946-952

[13] Th17 cells are increased with severity of liver inflammation in patients with chronic hepatitis C [J].

Chang, Qing ;

Wang, Yan-Kun ;

Zhao, Qing ;

Wang, Chang-Zheng ;

Hu, Ya-Zhuo ;

Wu, Ben-Yan .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 27 (02) :273-278

[14] HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function [J].

Chevalier, Mathieu F. ;

Juelg, Boris ;

Pyo, Augustine ;

Flanders, Michael ;

Ranasinghe, Srinika ;

Soghoian, Damien Z. ;

Kwon, Douglas S. ;

Rychert, Jenna ;

Lian, Jeffrey ;

Muller, Matthias I. ;

Cutler, Sam ;

McAndrew, Elizabeth ;

Jessen, Heiko ;

Pereyra, Florencia ;

Rosenberg, Eric S. ;

Altfeld, Marcus ;

Walker, Bruce D. ;

Streeck, Hendrik .

JOURNAL OF VIROLOGY, 2011, 85 (02) :733-741

[15] Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy [J].

Claassen, Mark A. A. ;

de Knegt, Robert J. ;

Turgut, Duygu ;

Groothuismink, Zwier M. A. ;

Janssen, Harry L. A. ;

Boonstra, Andre .

PLOS ONE, 2012, 7 (11)

[16] Retention of CD4+ CD25+ FoxP3+ Regulatory T Cells in the Liver after Therapy-Induced Hepatitis C Virus Eradication in Humans [J].

Claassen, Mark A. A. ;

de Knegt, Robert J. ;

Janssen, Harry L. A. ;

Boonstra, Andre .

JOURNAL OF VIROLOGY, 2011, 85 (11) :5323-5330

[17] Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis [J].

Claassen, Mark A. A. ;

de Knegt, Robert J. ;

Tilanus, Hugo W. ;

Janssen, Harry L. A. ;

Boonstra, Andre .

JOURNAL OF HEPATOLOGY, 2010, 52 (03) :315-321

[18] Routes of infection, viremia, and liver disease in blood donors found to have hepatitis C virus infection [J].

ConryCantilena, C ;

VanRaden, M ;

Gibble, J ;

Melpolder, J ;

Shakil, AO ;

Viladomiu, L ;

Cheung, L ;

DiBisceglie, A ;

Hoofnagle, J ;

Shih, JW ;

Kaslow, R ;

Ness, P ;

Alter, HJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (26) :1691-1696

[19] T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't [J].

Dolganiuc, Angela ;

Szabo, Gyongyi .

JOURNAL OF LEUKOCYTE BIOLOGY, 2008, 84 (03) :614-622

[20]

Dustin LB, 2007, ANNU REV IMMUNOL, V25, P71, DOI 10.1146/annurev.immunol.25.022106.141602

← 1 2 3 4 5 6 7 →