Role of T cell immunity in hepatitis C virus infections

被引：31

作者：

Claassen, Mark A. A. ^{[1
,2
]}

Janssen, Harry L. A. ^{[1
,3
]}

Boonstra, Andre ^{[1
]}

机构：

[1] Univ Med Ctr Rotterdam, Erasmus MC, Dept Gastroenterol & Hepatol, Liver Unit, Rotterdam, Netherlands

[2] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Infect Dis Unit, Rotterdam, Netherlands

[3] Univ Toronto, Div Gastroenterol, Liver Clin Univ Hlth Network, Toronto, ON M5S 1A1, Canada

来源：

CURRENT OPINION IN VIROLOGY | 2013年 / 3卷 / 04期

关键词：

GROWTH-FACTOR-BETA; IFN-ALPHA-BETA; PD-1; EXPRESSION; FUNCTIONAL RESTORATION; VIRAL PERSISTENCE; LIVER-DISEASE; TH17; CELLS; B-VIRUS; RESPONSES; CD4(+);

D O I：

10.1016/j.coviro.2013.05.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic infections with the hepatitis C virus (HCV) are a major global health issue. Viral replication is restricted to hepatocytes, and occurs for decades at high replication rates. Over the last decade, it became accepted that HCV-specific CD4(+) and CD8(+) T cells are crucial for protective immunity to HCV. However, a characteristic feature of persistent HCV infection is the dysfunctional T cell response, and over recent years enormous progress has been made in understanding the mechanisms that dampen the antiviral T cell responses in blood and liver of chronic HCV patients and also impact disease progression.

引用

收藏

页码：461 / 467

页数：7

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