Left Atrial Appendage Occlusion for The Unmet Clinical Needs of Stroke Prevention in Nonvalvular Atrial Fibrillation

被引：73

作者：

Holmes, David R., Jr. ^{[1
]}

Alkhouli, Mohamad ^{[2
]}

Reddy, Vivek ^{[3
]}

机构：

[1] Mayo Clin, Dept Cardiovasc Dis, 200 First St SW, Rochester, MN 55905 USA

[2] West Virginia Univ, Div Cardiol, Sch Med, Morgantown, WV 26506 USA

[3] Mt Sinai Med Ctr, Dept Med, Div Cardiol, Helmsley Electrophysiol Ctr, New York, NY 10029 USA

来源：

MAYO CLINIC PROCEEDINGS | 2019年 / 94卷 / 05期

关键词：

D O I：

10.1016/j.mayocp.2018.09.025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Oral anticoagulation is the dominant strategy for stroke prevention in patients with nonvalvular atrial fibrillation. However, lifelong oral anticoagulation is associated with major issues including inappropriate dosing, nonadherence, and adverse effects. Therefore, efforts have been made to develop site-specific therapy aimed to occlude the left atrial appendage, the anatomical site accountable for more than 90% of nonvalvular atrial fibrillation-related ischemic strokes. This review focuses on the growing literature to put into perspective the risk-balance ratio of left atrial appendage occlusion. (C) 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.

引用

页码：864 / 874

页数：11

共 51 条

[1] Burden of Atrial Fibrillation-Associated Ischemic Stroke in the United States [J].

Alkhouli, Mohamad ;

Alqahtani, Fahad ;

Aljohani, Sami ;

Alvi, Muhammad ;

Holmes, David R. .

JACC-CLINICAL ELECTROPHYSIOLOGY, 2018, 4 (05) :618-625

[2] Percutaneous Closure of Peridevice Leak After Left Atrial Appendage Occlusion [J].

Alkhouli, Mohamad ;

Alqahtani, Fahad ;

Kazienko, Brian ;

Olgers, Kassandra ;

Sengupta, Partho P. .

JACC-CARDIOVASCULAR INTERVENTIONS, 2018, 11 (11) :E83-E85

[3]

[Anonymous], 2017, J AM COLL CARDIOL, V69, P2779

[4]

[Anonymous], 2016, J AM HEART ASS

[5] Percutaneous Left Atrial Appendage Closure: Current Devices and Clinical Outcomes [J].

Asmarats, Lluis ;

Rodes-Cabau, Josep .

CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2017, 10 (11)

[6] Performance of the subcutaneous implantable cardioverter-defibrillator in patients with a primary prevention indication with and without a reduced ejection fraction versus patients with a secondary prevention indication [J].

Boersma, Lucas V. ;

Barr, Craig S. ;

Burke, Martin C. ;

Leon, Angel R. ;

Theuns, Dominic A. ;

Herre, John M. ;

Weiss, Raul ;

Kremers, Mark S. ;

Neuzil, Petr ;

Husby, Michael P. ;

Carter, Nathan ;

Stivland, Timothy M. ;

Gold, Michael R. .

HEART RHYTHM, 2017, 14 (03) :367-375

[7]

Ellis Christopher R, 2017, JACC Clin Electrophysiol, V3, P1356, DOI 10.1016/j.jacep.2017.03.008

[8] Comparison of Efficacy and Safety of Left Atrial Appendage Occlusion in Patients Aged <75 to ≥75 Years [J].

Freixa, Xavier ;

Gafoor, Sameer ;

Regueiro, Ander ;

Cruz-Gonzalez, Ignacio ;

Shakir, Samera ;

Omran, Heyder ;

Berti, Sergio ;

Santoro, Gennaro ;

Kefer, Joelle ;

Landmesser, Ulf ;

Nielsen-Kudsk, Jens Erik ;

Sievert, Horst ;

Kanagaratnam, Prapa ;

Nietlispach, Fabian ;

Gloekler, Steffen ;

Aminian, Adel ;

Danna, Paolo ;

Rezzaghi, Marco ;

Stock, Friederike ;

Stolcova, Miroslava ;

Costa, Marco ;

Ibrahim, Reda ;

Schillinger, Wolfgang ;

Park, Jai-Wun ;

Meier, Bernhard ;

Tzikas, Apostolos .

AMERICAN JOURNAL OF CARDIOLOGY, 2016, 117 (01) :84-90

[9] Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: a randomised non-inferiority trial [J].

Holmes, David R. ;

Reddy, Vivek Y. ;

Turi, Zoltan G. ;

Doshi, Shephal K. ;

Sievert, Horst ;

Buchbinder, Maurice ;

Mullin, Christopher M. ;

Sick, Peter .

LANCET, 2009, 374 (9689) :534-542

[10] 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS [J].

Kirchhof, Paulus ;

Benussi, Stefano ;

Kotecha, Dipak ;

Ahlsson, Anders ;

Atar, Dan ;

Casadei, Barbara ;

Castella, Manuel ;

Diener, Hans-Christoph ;

Heidbuchel, Hein ;

Hendriks, Jeroen ;

Hindricks, Gerhard ;

Manolis, Antonis S. ;

Oldgren, Jonas ;

Popescu, Bogdan Alexandru ;

Schotten, Ulrich ;

Van Putte, Bart ;

Vardas, Panagiotis .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2016, 50 (05) :E1-E88

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