Cytokine profiles in children with primary Epstein-Barr virus infection

被引：44
作者：
Wada, Taizo [1 ]
Muraoka, Masahiro [1 ]
Yokoyama, Tadafumi [1 ]
Toma, Tomoko [1 ]
Kanegane, Hirokazu [2 ]
Yachie, Akihiro [1 ]
机构：
[1] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Sch Med, Dept Pediat, Kanazawa, Ishikawa 9208641, Japan
[2] Toyama Univ, Dept Pediat, Grad Sch Med & Pharmaceut Sci, Toyama 930, Japan
来源：
PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 07期
关键词：
cytokine; EpsteinBarr virus; hemophagocytic lymphohistiocytosis; infectious mononucleosis; HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; HEME OXYGENASE-1; T-LYMPHOCYTES; MONONUCLEOSIS; ACTIVATION; DIAGNOSIS; PATTERN;
D O I：
10.1002/pbc.24480
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary EpsteinBarr virus (EBV) infection causes infectious mononucleosis and hemophagocytic lymphohistiocytosis (HLH) in children, where EBV infects B and CD8+ T cells, respectively. We measured pro-inflammatory and anti-inflammatory cytokines in both diseases. Significantly higher concentrations of various mediators, including interferon-, neopterin, interleukin (IL)-6, IL-10, IL-18, and heme oxygenase-1, were observed in EBV-HLH. Because of their similarity to the profile of familial HLH, this profile was likely a consequence of HLH, but not ectopic infection. TNF- levels were elevated in both diseases. Elevation of those mediators may contribute to the disease pathogenesis of EBV-HLH by activating and inhibiting host immune responses. Pediatr Blood Cancer 2013; 60: E46E48. (c) 2013 Wiley Periodicals, Inc.
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页码：E46 / E48
页数：3
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