Regulation and function of pyruvate kinase M2 in cancer

被引：159

作者：

Yang, Weiwei ^{[1
,2
]}

Lu, Zhimin ^{[1
,2
,3
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Brain Tumor Ctr, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[4] Univ Texas Houston, Grad Sch Biomed Sci, Houston, TX 77030 USA

来源：

CANCER LETTERS | 2013年 / 339卷 / 02期

关键词：

PKM2; The Warburg effect; Gene expression; NUCLEAR TRANSLOCATION; GENE-TRANSCRIPTION; ISOFORM M2; PKM2; EXPRESSION; PROMOTES; PHOSPHORYLATION; IDENTIFICATION; GLYCOLYSIS; ISOENZYME;

D O I：

10.1016/j.canlet.2013.06.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Altered metabolism is fundamental to the growth and survival of cancer cells. Pyruvate kinase M2 (PKM2), a key enzyme in cancer metabolism, has been demonstrated to play a central role not only in metabolic reprogramming but also in direct regulation of gene expression and subsequent cell cycle progression. This review outlines the current understanding of PKM2 protein kinase activity and regulatory mechanisms underlying PKM2 expression, enzymatic activity, and nuclear localization, thus highlighting PKM2 as a potential therapeutic target. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：153 / 158

页数：6

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