Outer membrane vesicle A macromolecule with multifunctional activity

被引：13

作者：

Moshiri, Arfa ^{[2
]}

Dashtbani-Roozbehani, Abolfazl ^{[3
]}

Peerayeh, Shahin Najar ^{[4
]}

Siadat, Seyed Davar ^{[1
]}

机构：

[1] Pasteur Inst Iran, Dept Microbiol, Tehran, Iran

[2] Univ Tehran Med Sci, Sch Allied Med Sci, Dept Biotechnol, Tehran, Iran

[3] Pasteur Inst Iran, Dept Hepatitis & AIDS, Tehran, Iran

[4] Tarbiat Modares Univ, Fac Med Sci, Dept Bacteriol, Tehran, Iran

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2012年 / 8卷 / 07期

关键词：

adjuvant; outer membrane vesicle; Neisseria meningitidis; vaccine development; NEISSERIA-MENINGITIDIS-SEROGROUP; ADJUVANT; LACTAMICA; LIPOPOLYSACCHARIDE; IMMUNIZATION; RESPONSES; VACCINE;

D O I：

10.4161/hv.20166

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nowadays adjuvants are extensively used as immuno-stimulatory and immuno-modulatory compounds as components of subunit and combination vaccine formulations. The adjuvants of microbial origin are more frequently used among currently used licensed or experimental adjuvants. The outer membrane vesicle (OMV) of Neisseria meningitidis is among the newly studied components of microbial origin, which could be applied as an adjuvant. Although the potency of OMV as a carrier (conjugated to a hapten) is now proven, the adjuvant properties of OMV have particular significance as a potential target for protective immunity. Since it has immune-stimulatory activity, OMV has been utilized in vaccine development. This commentary reviews the different applications of OMV as potential adjuvant in the field of vaccine development.

引用

页码：953 / 955

页数：3

共 14 条

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