Pre-transplant levels of ficolin-3 are associated with kidney graft survival

被引：14

作者：

Bay, Jakob T. ^{[1
]}

Hein, Estrid ^{[1
]}

Sorensen, Soren S. ^{[2
]}

Hansen, Jesper Melchior ^{[3
]}

Garred, Peter ^{[1
]}

机构：

[1] Univ Copenhagen, Rigshosp, Dept Clin Immunol, Mol Med Lab, DK-2100 Copenhagen, Denmark

[2] Univ Copenhagen, Rigshosp, Dept Nephrol P, DK-2100 Copenhagen, Denmark

[3] Univ Copenhagen, Fac Hlth Sci, Herlev Hosp, Dept Nephrol, Copenhagen, Denmark

来源：

CLINICAL IMMUNOLOGY | 2013年 / 146卷 / 03期

关键词：

Kidney transplantation; Ficolins; Lectin pathway; Complement; HAKATA ANTIGEN; LECTIN PATHWAY; COMPLEMENT; ACTIVATION; FCN2;

D O I：

10.1016/j.clim.2013.01.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ficolin-3 is an initiator of the lectin complement pathway. The complement system is a mediator of the pathophysiology of graft rejection in kidney transplantation, but the role of ficolin-3 in this process is unknown. Using a prospective study design, 527 kidney transplanted patients were included. 97 blood donors served as controls. Ficolin-3, C4 and C3 were measured in pre-transplant as well as in control serum samples. In controls, deposition of ficolin-3, C4, C3 and the terminal complement complex (TCC) was measured in an assay based on acetylated albumin as matrix. The ficolin-3 levels correlated with the serum levels of C4 and C3. The serum levels of ficolin-3 correlated with the deposition of ficolin-3, C4, C3 and TCC. Survival analyses showed that high pre-transplant serum levels of ficolin-3 were associated with decreased graft survival. These results suggest an important role of ficolin-3 in the pathophysiology of kidney graft rejection. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：240 / 247

页数：8

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