Lactulose enhances neuroplasticity to improve cognitive function in early hepatic encephalopathy

被引：12
作者：
Yang, Nan
Liu, He
Jiang, Yao
Zheng, Ji
Li, Dong-mei
Ji, Chao
Liu, Yan-yong [1 ]
Zuo, Ping-ping
机构：
[1] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Pharmacol, Beijing 100730, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2015年 / 10卷 / 09期
基金：
中国国家自然科学基金;
关键词：
nerve regeneration; brain injury; hepatic encephalopathy; lactulose; neuroplasticity; neurogenesis; Morris water maze; cognition; rats; neuronal nuclei; glial fibrillary acidic protein; NSFC grants; neural regeneration; FIBRILLARY ACIDIC PROTEIN; ADULT NEUROGENESIS; LIVER-DISEASE; AMMONIA; BRAIN; CIRRHOSIS; RAT; METABOLISM; ASTROCYTES; EXPRESSION;
D O I：
10.4103/1673-5374.165516
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lactulose is known to improve cognitive function in patients with early hepatic encephalopathy; however, the underlying mechanism remains poorly understood. In the present study, we investigated the behavioral and neurochemical effects of lactulose in a rat model of early hepatic encephalopathy induced by carbon tetrachloride. Immunohistochemistry showed that lactulose treatment promoted neurogenesis and increased the number of neurons and astrocytes in the hippocampus. Moreover, lactulose-treated rats showed shorter escape latencies than model rats in the Morris water maze, indicating that lactulose improved the cognitive impairments caused by hepatic encephalopathy. The present findings suggest that lactulose effectively improves cognitive function by enhancing neuroplasticity in a rat model of early hepatic encephalopathy.
引用
收藏
页码：1457 / 1462
页数：6
相关论文
共 35 条
[1]   Loss of expression of glial fibrillary acidic protein in acute hyperammonemia [J].
Bélanger, M ;
Desjardins, P ;
Chatauret, N ;
Butterworth, RF .
NEUROCHEMISTRY INTERNATIONAL, 2002, 41 (2-3) :155-160
[2]   Hepatic encephalopathy [J].
Blei, AT ;
Córdoba, J .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2001, 96 (07) :1968-1976
[3]   Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure [J].
Chastre, Anne ;
Jiang, Wenlei ;
Desjardins, Paul ;
Butterworth, Roger F. .
METABOLIC BRAIN DISEASE, 2010, 25 (01) :17-21
[4]   Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen [J].
Chen, Xiao ;
Zhai, Xiao ;
Kang, Zhimin ;
Sun, Xuejun .
MEDICAL GAS RESEARCH, 2012, 2
[5]   Comparative aspects of cortical neurogenesis in vertebrates [J].
Cheung, Amanda F. P. ;
Pollen, Alexander A. ;
Tavare, Aniket ;
DeProto, Jamin ;
Molnar, Zoltan .
JOURNAL OF ANATOMY, 2007, 211 (02) :164-176
[6]   Neurobiology of ammonia [J].
Felipo, V ;
Butterworth, RF .
PROGRESS IN NEUROBIOLOGY, 2002, 67 (04) :259-279
[7]   Hepatic encephalopathy: effects of liver failure on brain function [J].
Felipo, Vicente .
NATURE REVIEWS NEUROSCIENCE, 2013, 14 (12) :851-858
[8]   Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: Final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 [J].
Ferenci, P ;
Lockwood, A ;
Mullen, K ;
Tarter, R ;
Weissenborn, K ;
Blei, AT .
HEPATOLOGY, 2002, 35 (03) :716-721
[9]   Oxidative Stress Markers in the Brain of Patients with Cirrhosis and Hepatic Encephalopathy [J].
Goerg, Boris ;
Qvartskhava, Natalia ;
Bidmon, Hans-Juergen ;
Palomero-Gallagher, Nicola ;
Kircheis, Gerald ;
Zilles, Karl ;
Haeussinger, Dieter .
HEPATOLOGY, 2010, 52 (01) :256-265
[10]   Hepatic encephalopathy in chronic liver disease:: a clinical manifestation of astrocyte swelling and low-grade cerebral edema? [J].
Häussinger, D ;
Kircheis, G ;
Fischer, R ;
Schliess, F ;
vom Dahl, S .
JOURNAL OF HEPATOLOGY, 2000, 32 (06) :1035-1038
1234