Immunity to hepatitis C virus: stunned but not defeated

被引：24

作者：

Klenerman, P ^{[1
]}

Lucas, M ^{[1
]}

Barnes, E ^{[1
]}

Harcourt, G ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Oxford OX1 3SY, England

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 01期

基金：

英国惠康基金;

关键词：

HCV; CD8+T lymphocyte; tetramer; CD4+T lymphocyte; NKT cell;

D O I：

10.1016/S1286-4579(01)01510-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis C virus (HCV) readily causes a persistent infection, although some individuals spontaneously control infection. 'Successful' immune responses appear to be multi-specific and sustained-including a major role for CD4+ T cells. Some antiviral CD8+ T cells show reduced capacity to secrete antiviral cytokines either temporarily ('stunning') or in the long term ('stunting'). The co-ordination of multiple immune effector functions may be required to gain control of HCV. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：57 / 65

页数：9

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