S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis

被引：74
|
作者：
Selvakumar, Balakrishnan [1 ]
Jenkins, Meagan A. [5 ]
Hussain, Natasha K. [1 ]
Huganir, Richard L. [1 ,4 ]
Traynelis, Stephen F. [5 ]
Snyder, Solomon H. [1 ,2 ,3 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA
[5] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 03期
关键词：
LONG-TERM POTENTIATION; PROTEIN-KINASE-II; NITRIC-OXIDE; GLUTAMATE RECEPTORS; SYNAPTIC PLASTICITY; MEDIATED TRANSMISSION; SURFACE EXPRESSION; ENDOTHELIAL-CELLS; GLUR1; SUBUNIT; C ACTIVITY;
D O I：
10.1073/pnas.1221295110
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
NMDA receptor activation can elicit synaptic plasticity by augmenting conductance of the AMPA receptor GluA1 subsequent to phosphorylation at S831 by Ca2+-dependent kinases. NMDA receptor activation also regulates synaptic plasticity by causing endocytosis of AMPA receptor GluA1. We demonstrate a unique signaling cascade for these processes mediated by NMDA receptor-dependent NO formation and GluA1 S-nitrosylation. Thus, S-nitrosylation of GluA1 at C875 enhances S831 phosphorylation, facilitates the associated AMPA receptor conductance increase, and results in endocytosis by increasing receptor binding to the AP2 protein of the endocytotic machinery.
引用
收藏
页码：1077 / 1082
页数：6
相关论文
共 28 条
  • [21] Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy
    Chung, Heaseung Sophia
    Kim, Grace E.
    Holewinski, Ronald J.
    Venkatraman, Vidya
    Zhu, Guangshuo
    Bedja, Djahida
    Kass, David A.
    Van Eyk, Jennifer E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (50) : E10763 - E10771
  • [22] Spinal AMPA Receptor GluA1 Ser831 Phosphorylation Controls Chronic Alcohol Consumption-Produced Prolongation of Postsurgical Pain
    Liu, Sufang
    Zhao, Zhiying
    Guo, Yan
    Shu, Hui
    Li, Changsheng
    Tang, Yuanyuan
    Xing, Ying
    Tao, Feng
    MOLECULAR NEUROBIOLOGY, 2018, 55 (05) : 4090 - 4097
  • [23] Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Regulates the Stability and Function of GluA1 α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid (AMPA) Receptor in Neurons
    Gan, Ming
    Jiang, Peizhou
    McLean, Pamela
    Kanekiyo, Takahisa
    Bu, Guojun
    PLOS ONE, 2014, 9 (12):
  • [24] P2X-mediated AMPA receptor internalization and synaptic depression is controlled by two CaMKII phosphorylation sites on GluA1 in hippocampal neurons
    Pougnet, Johan-Till
    Compans, Benjamin
    Martinez, Audrey
    Choquet, Daniel
    Hosy, Eric
    Boue-Grabot, Eric
    SCIENTIFIC REPORTS, 2016, 6
  • [25] Mechanism of Inhibition of the GluA1 AMPA Receptor Channel Opening by the 2,3-Benzodiazepine Compound GYKI 52466 and a N-Methyl-Carbamoyl Derivative
    Wu, Andrew
    Wang, Congzhou
    Niu, Li
    BIOCHEMISTRY, 2014, 53 (18) : 3033 - 3041
  • [26] M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt
    Zhao, Lan-Xue
    Ge, Yan-Hui
    Li, Jia-Bing
    Xiong, Cai-Hong
    Law, Ping-Yee
    Xu, Jian-Rong
    Qiu, Yu
    Chen, Hong-Zhuan
    FASEB JOURNAL, 2019, 33 (05) : 6622 - 6631
  • [27] Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: Evidence for Wagner's dual-process memory model
    Sanderson, David J.
    McHugh, Stephen B.
    Good, Mark A.
    Sprengel, Rolf
    Seeburg, Peter H.
    Rawlins, J. Nicholas P.
    Bannerman, David M.
    NEUROPSYCHOLOGIA, 2010, 48 (08) : 2303 - 2315
  • [28] Prolonged Adenosine A1 Receptor Activation in Hypoxia and Pial Vessel Disruption Focal Cortical Ischemia Facilitates Clathrin-Mediated AMPA Receptor Endocytosis and Long-Lasting Synaptic Inhibition in Rat Hippocampal CA3-CA1 Synapses: Differential Regulation of GluA2 and GluA1 Subunits by p38 MAPK and JNK
    Chen, Zhicheng
    Xiong, Cherry
    Pancyr, Cassandra
    Stockwell, Jocelyn
    Walz, Wolfgang
    Cayabyab, Francisco S.
    JOURNAL OF NEUROSCIENCE, 2014, 34 (29) : 9621 - 9643
123