Milk fat globule membrane - a source of polar lipids for colon health? A review

被引：34

作者：

Kuchta, Anna M. ^{[1
,2
]}

Kelly, Philip M. ^{[3
]}

Stanton, Catherine ^{[1
]}

Devery, Rosaleen A. ^{[4
]}

机构：

[1] TEAGASC, Moorepk Food Res Ctr, Food BioSci Dept, Fermoy, Cork, Ireland

[2] Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland

[3] TEAGASC, Moorepk Food Res Ctr, Food Proc & Funct Dept, Fermoy, Cork, Ireland

[4] Dublin City Univ, Natl Inst Cellular Biotechnol, Dublin 9, Ireland

来源：

INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY | 2012年 / 65卷 / 03期

关键词：

Milk fat globule membrane; Colon cancer; Phospholipids; Sphingolipids; INTESTINAL ALKALINE SPHINGOMYELINASE; NECROSIS-FACTOR-ALPHA; ACID-BINDING PROTEIN; BREAST-CANCER CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; 1,2-DIMETHYLHYDRAZINE-TREATED CF1 MICE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; FAMILIAL ADENOMATOUS POLYPOSIS; CHOLINE KINASE-ACTIVITY; ABERRANT CRYPT FOCI;

D O I：

10.1111/j.1471-0307.2011.00759.x

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The milk fat globule membrane (MFGM) surrounds fat globules, protects them against lipolysis and disperses the milk fat in the milk plasma. Besides their structural and emulsifying roles, in vivo and in vitro studies have demonstrated that phospholipids and sphingolipids of MFGM possess cancer risk-reducing properties. Several reports attribute its chemopreventive activity to products of sphingomyelin hydrolysis, which affect multiple cellular targets that control cell growth, differentiation and apoptosis. With knowledge on the potential health benefits of MFGM lipids and proteins, dairy industries could in the future address their research in developing new functional dairy products enriched in beneficial MFGM components.

引用

页码：315 / 333

页数：19

共 188 条

[31] Effects of bile diversion in rats on intestinal sphingomyelinases and ceramidase [J].

Duan, R. D. ;

Verkade, H. J. ;

Cheng, Y. ;

Havinga, R. ;

Nilsson, A. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2007, 1771 (02) :196-201

[32] Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family [J].

Duan, RD ;

Bergman, T ;

Xu, N ;

Wu, J ;

Cheng, Y ;

Duan, JX ;

Nelander, S ;

Palmberg, C ;

Nilsson, Å .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) :38528-38536

[33] Distribution of alkaline sphingomyelinase activity in human beings and animals - Tissue and species differences [J].

Duan, RD ;

Hertervig, E ;

Nyberg, L ;

Hauge, T ;

Sternby, B ;

Lillienau, J ;

Farooqi, A ;

Nilsson, A .

DIGESTIVE DISEASES AND SCIENCES, 1996, 41 (09) :1801-1806

[34] Sphingomyelin hydrolysis in the gut and clinical implications in colorectal tumorigenesis and other gastrointestinal diseases [J].

Duan, RD .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1998, 33 (07) :673-683

[35]

Duan RD, 1997, HEPATOLOGY, V26, P823, DOI 10.1002/hep.510260403

[36] Sphingomyelinase and ceramidase in the intestinal tract [J].

Duan, Rui-Dong .

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2007, 109 (10) :987-993

[37] Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development [J].

Duan, Rui-Dong ;

Nilsson, Ake .

PROGRESS IN LIPID RESEARCH, 2009, 48 (01) :62-72

[38]

Duan RuiDong Duan RuiDong, 2006, Scandinavian Journal of Food & Nutrition, V50, P45, DOI 10.1080/17482970601075703

[39] THE ROLE OF SPHINGOMYELIN SYNTHETASE AND SPHINGOMYELINASE IN 1,2-DIMETHYLHYDRAZINE-INDUCED LIPID ALTERATIONS OF RAT COLONIC PLASMA-MEMBRANES [J].

DUDEJA, PK ;

DAHIYA, R ;

BRASITUS, TA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 863 (02) :309-312

[40]

Dueck DA, 1996, MOL CELL BIOCHEM, V162, P97

← 1 2 3 4 5 6 7 8 9 10 →