Milk fat globule membrane - a source of polar lipids for colon health? A review

被引：34
作者：
Kuchta, Anna M. [1 ,2 ]
Kelly, Philip M. [3 ]
Stanton, Catherine [1 ]
Devery, Rosaleen A. [4 ]
机构：
[1] TEAGASC, Moorepk Food Res Ctr, Food BioSci Dept, Fermoy, Cork, Ireland
[2] Dublin City Univ, Sch Biotechnol, Dublin 9, Ireland
[3] TEAGASC, Moorepk Food Res Ctr, Food Proc & Funct Dept, Fermoy, Cork, Ireland
[4] Dublin City Univ, Natl Inst Cellular Biotechnol, Dublin 9, Ireland
来源：
INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY | 2012年 / 65卷 / 03期
关键词：
Milk fat globule membrane; Colon cancer; Phospholipids; Sphingolipids; INTESTINAL ALKALINE SPHINGOMYELINASE; NECROSIS-FACTOR-ALPHA; ACID-BINDING PROTEIN; BREAST-CANCER CELLS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; 1,2-DIMETHYLHYDRAZINE-TREATED CF1 MICE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; FAMILIAL ADENOMATOUS POLYPOSIS; CHOLINE KINASE-ACTIVITY; ABERRANT CRYPT FOCI;
D O I：
10.1111/j.1471-0307.2011.00759.x
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The milk fat globule membrane (MFGM) surrounds fat globules, protects them against lipolysis and disperses the milk fat in the milk plasma. Besides their structural and emulsifying roles, in vivo and in vitro studies have demonstrated that phospholipids and sphingolipids of MFGM possess cancer risk-reducing properties. Several reports attribute its chemopreventive activity to products of sphingomyelin hydrolysis, which affect multiple cellular targets that control cell growth, differentiation and apoptosis. With knowledge on the potential health benefits of MFGM lipids and proteins, dairy industries could in the future address their research in developing new functional dairy products enriched in beneficial MFGM components.
引用
收藏
页码：315 / 333
页数：19
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