Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome in a patient with chronic hepatitis B infection

被引：0

作者：

Nunez Martinez, Oscar ^{[1
]}

Marquina Ibanez, Isabel ^{[2
]}

Ruiz Bravo-Burguillos, Elena ^{[3
]}

Encinas Sotillos, Alfonso ^{[1
]}

Erdozain Sosa, Jose Carlos ^{[1
]}

机构：

[1] Hosp Univ Infanta Sofia, Unidad Digest, Madrid, Spain

[2] Hosp Univ Infanta Sofia, Serv Anat Patol, Madrid, Spain

[3] Hosp Univ La Paz, Serv Anat Patol, Madrid, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2013年 / 36卷 / 06期

关键词：

Primary biliary; cirrhosis; Overlap syndrome; Liver biopsy; VIRUS INFECTION; DIAGNOSIS; THERAPY; MANAGEMENT; FEATURES; CRITERIA;

D O I：

10.1016/j.gastrohep.2012.07.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We describe the case of a female patient with a previous diagnosis of primary biliary cirrhosis (PBC) and chronic hepatitis B in inactive phase who developed increased transaminase levels with no evidence of hepatitis B virus reactivation while receiving ursodeoxycholic acid treatment. A liver biopsy showed changes compatible with overlapping autoimmune hepatitis (AIH). Budesonide treatment achieved normalization of transaminase levels. We provide a review of PBC and AIH overlap syndrome and discuss the particular features of this case that led us to this diagnosis, as well as the treatment provided. (C) 2012 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.

引用

页码：382 / 387

页数：6

共 25 条

[1] International Autoimmune Hepatitis Group Report:: review of criteria for diagnosis of autoimmune hepatitis [J].

Alvarez, E ;

Berg, PA ;

Bianchi, FB ;

Bianchi, L ;

Burroughs, AK ;

Cancado, EL ;

Chapman, RW ;

Cooksley, WGE ;

Czaja, AJ ;

Desmet, VJ ;

Donaldson, RT ;

Eddleston, ALWF ;

Fainboim, L ;

Heathcote, J ;

Homberg, JC ;

Hoofnagle, JH ;

Kakumu, S ;

Krawitt, EL ;

Mackay, IR ;

MacSween, RNM ;

Maddrey, WC ;

Manns, MP ;

McFarlane, IG ;

zum Büschenfelde, KHM ;

Mieli-Vergani, G ;

Nakanuma, Y ;

Nishioka, M ;

Penner, E ;

Porta, G ;

Portmann, BC ;

Reed, WD ;

Rodes, J ;

Schalm, SW ;

Scheuer, PJ ;

Schrumpf, E ;

Seki, T ;

Toda, G ;

Tsuji, T ;

Tygstrup, N ;

Vergani, D ;

Zeniya, M .

JOURNAL OF HEPATOLOGY, 1999, 31 (05) :929-938

[2]

[Anonymous], 2009, J HEPATOL, V31, P1005

[3] Autoimmune hepatitis and its variant syndromes [J].

Ben-Ari, Z ;

Czaja, AJ .

GUT, 2001, 49 (04) :589-594

[4] Overlap syndromes: The International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue [J].

Boberg, Kirsten Muri ;

Chapman, Roger W. ;

Hirschfield, Gideon M. ;

Lohse, Ansgar W. ;

Manns, Michael P. ;

Schrumpf, Erik .

JOURNAL OF HEPATOLOGY, 2011, 54 (02) :374-385

[5] Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome [J].

Chazouillères, O ;

Wendum, D ;

Serfaty, L ;

Rosmorduc, O ;

Poupon, R .

JOURNAL OF HEPATOLOGY, 2006, 44 (02) :400-406

[6] Primary biliary cirrhosis autoimmune hepatitis overlap syndrome:: Clinical features and response to therapy [J].

Chazouillères, O ;

Wendum, D ;

Serfaty, L ;

Montembault, S ;

Rosmorduc, O ;

Poupon, R .

HEPATOLOGY, 1998, 28 (02) :296-301

[7] Performance Parameters of the Diagnostic Scoring Systems for Autoimmune Hepatitis [J].

Czaja, Albert J. .

HEPATOLOGY, 2008, 48 (05) :1540-1548

[8] Comparability of Probable and Definite Autoimmune Hepatitis by International Diagnostic Scoring Criteria [J].

Czaja, Albert J. .

GASTROENTEROLOGY, 2011, 140 (05) :1472-1480

[9] Occult hepatitis B virus infection in patients with autoimmune liver diseases [J].

Georgiadou, Sarah P. ;

Zachou, Kalliopi ;

Liaskos, Christos ;

Gabeta, Stella ;

Rigopoulou, Eirini I. ;

Dalekos, George N. .

LIVER INTERNATIONAL, 2009, 29 (03) :434-442

[10]

Gregorio GV, 1999, J IMMUNOL, V162, P1802

← 1 2 3 →