Time-dependent information transmission in a model regulatory circuit

被引：14

作者：

Mancini, F. ^{[1
]}

Wiggins, C. H. ^{[2
]}

Marsili, M. ^{[3
]}

Walczak, A. M. ^{[4
,5
]}

机构：

[1] Int Sch Adv Studies SISSA, Trieste, Italy

[2] Columbia Univ, Ctr Computat Biol & Bioinformat, Dept Appl Phys & Appl Math, New York, NY 10027 USA

[3] Abdus Salam Int Ctr Theoret Phys ICTP, Trieste, Italy

[4] Ecole Normale Super, CNRS, Paris, France

[5] Ecole Normale Super, Phys Theor Lab, F-75231 Paris, France

来源：

PHYSICAL REVIEW E | 2013年 / 88卷 / 02期

关键词：

LOOP;

D O I：

10.1103/PhysRevE.88.022708

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

Many biological regulatory systems respond with a physiological delay when processing signals. A simple model of regulation which respects these features shows how the ability of a delayed output to transmit information is limited: at short times by the time scale of the dynamic input, at long times by that of the dynamic output. We find that topologies of maximally informative networks correspond to commonly occurring biological circuits linked to stress response and that circuits functioning out of steady state may exploit absorbing states to transmit information optimally.

引用

页数：12

共 33 条

[1]

Alberts B., 2010, Essential Cell Biology, VThird

[2] Network motifs: theory and experimental approaches [J].