Nuclear Receptor LXR: A New Partner for Sodium-Dependent Phosphate Cotransporters

被引：5
作者：
Caldas, Yupanqui [1 ,2 ]
Giral, Hector [1 ]
Sorribas, Victor [2 ]
Levi, Moshe [1 ]
机构：
[1] Univ Colorado Denver, Aurora, CO 80045 USA
[2] Univ Zaragoza, Zaragoza, Spain
来源：
PHOSPHATE AND VITAMIN D IN CHRONIC KIDNEY DISEASE | 2013年 / 180卷
关键词：
P-I COTRANSPORTER; PARATHYROID-HORMONE; RETINOIC ACID; PIT-2; SLC20A2; RAT; TRANSPORTER; HOMEOSTASIS; REABSORPTION; EXPRESSION; MEMBRANE;
D O I：
10.1159/000346782
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
New pharmaceutical research approaches are focusing on trying to alleviate the perturbed phosphate (Pi) homeostasis associated with the onset of chronic kidney disease; this includes activation of some of the nuclear receptors. We have recently reported the down regulation of the intestinal and renal sodium-phosphate (NaPi) cotransporters by the liver X receptor (LXR) agonists, and the consequent decrease of the serum Pi levels. In this review, we describe our current knowledge of the different proteins involved in the renal and intestinal actions of LXR. Copyright (C) 2013 S. Karger AG, Basel
引用
收藏
页码：64 / 73
页数：10
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