In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1

被引：59

作者：

Gravina, H. D. ^{[1
,2
]}

Tafuri, N. F. ^{[1
,2
]}

Silva Junior, A. ^{[1
,2
]}

Fietto, J. L. R. ^{[1
,2
]}

Oliveira, T. T. ^{[3
]}

Diaz, M. A. N. ^{[4
]}

Almeida, M. R. ^{[1
,2
]}

机构：

[1] Univ Fed Vicosa, Mol Anim Infectol Lab, Appl Biotechnol Inst BIOAGRO, BR-36570000 Vicosa, MG, Brazil

[2] Univ Fed Vicosa, Anim Virol Lab, Dept Vet Sci, BR-36570000 Vicosa, MG, Brazil

[3] Univ Fed Vicosa, Biofarmacos Lab, Dept Biochem & Mol Biol, BR-36570000 Vicosa, MG, Brazil

[4] Univ Fed Vicosa, Biomol Chem Lab, Dept Biochem & Mol Biol, BR-36570000 Vicosa, MG, Brazil

来源：

RESEARCH IN VETERINARY SCIENCE | 2011年 / 91卷 / 03期

关键词：

Antiviral activity; Flavonoids; EHV-1; EQUINE HERPESVIRUS-1; EXTRACTS; INHIBITION; GROWTH; FLAVONOIDS; DRUGS;

D O I：

10.1016/j.rvsc.2010.11.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The antiviral activity of quercetin, morin and trans-cinnamic acid was evaluated in vitro against equid herpesvirus 1 (EHV-1) by determining the virucidal activity and using the time of addition assay to test inhibition of the viral replication cycle. The cytotoxicity of each substance was assessed using MTT [3-(4,5-dimethylthiazo1-2-yl)-2,5-diphenyltetrazolium bromide]. Quercetin showed virucidal action and inhibition of the viral replication cycle at 0 and 1 h. Morin showed potential virucidal and viral replication cycle inhibition at 0 h. Trans-cinnamic acid did not show virucidal activity but inhibited the viral replication cycle at 1 and 0 h. This study demonstrates the potential of these compounds as future antiviral candidates in relation to viruses of importance in veterinary medicine. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：E158 / E162

页数：5

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