In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1

被引：59
作者：
Gravina, H. D. [1 ,2 ]
Tafuri, N. F. [1 ,2 ]
Silva Junior, A. [1 ,2 ]
Fietto, J. L. R. [1 ,2 ]
Oliveira, T. T. [3 ]
Diaz, M. A. N. [4 ]
Almeida, M. R. [1 ,2 ]
机构：
[1] Univ Fed Vicosa, Mol Anim Infectol Lab, Appl Biotechnol Inst BIOAGRO, BR-36570000 Vicosa, MG, Brazil
[2] Univ Fed Vicosa, Anim Virol Lab, Dept Vet Sci, BR-36570000 Vicosa, MG, Brazil
[3] Univ Fed Vicosa, Biofarmacos Lab, Dept Biochem & Mol Biol, BR-36570000 Vicosa, MG, Brazil
[4] Univ Fed Vicosa, Biomol Chem Lab, Dept Biochem & Mol Biol, BR-36570000 Vicosa, MG, Brazil
来源：
RESEARCH IN VETERINARY SCIENCE | 2011年 / 91卷 / 03期
关键词：
Antiviral activity; Flavonoids; EHV-1; EQUINE HERPESVIRUS-1; EXTRACTS; INHIBITION; GROWTH; FLAVONOIDS; DRUGS;
D O I：
10.1016/j.rvsc.2010.11.010
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The antiviral activity of quercetin, morin and trans-cinnamic acid was evaluated in vitro against equid herpesvirus 1 (EHV-1) by determining the virucidal activity and using the time of addition assay to test inhibition of the viral replication cycle. The cytotoxicity of each substance was assessed using MTT [3-(4,5-dimethylthiazo1-2-yl)-2,5-diphenyltetrazolium bromide]. Quercetin showed virucidal action and inhibition of the viral replication cycle at 0 and 1 h. Morin showed potential virucidal and viral replication cycle inhibition at 0 h. Trans-cinnamic acid did not show virucidal activity but inhibited the viral replication cycle at 1 and 0 h. This study demonstrates the potential of these compounds as future antiviral candidates in relation to viruses of importance in veterinary medicine. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：E158 / E162
页数：5
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