Papillary tumor of the pineal region: a case involving isocitrate dehydrogenase (IDH) genotyping

被引：7

作者：

Ishida, Atsushi ^{[1
]}

Shibuya, Makoto ^{[2
]}

Komori, Takashi ^{[3
]}

Nobusawa, Sumihito ^{[4
]}

Niimura, Kaku ^{[1
]}

Matsuo, Seigo ^{[1
]}

Hori, Tomokatsu ^{[1
]}

机构：

[1] Moriyama Mem Hosp, Dept Neurosurg, Edogawa Ku, Tokyo 1348608, Japan

[2] Tokyo Med Univ, Ibaraki Med Ctr, Dept Pathol, Ibaraki, Japan

[3] Tokyo Metropolitan Inst Neurosci, Dept Clin Neuropathol, Tokyo, Japan

[4] Gunma Univ, Dept Pathol, Maebashi, Gunma 371, Japan

来源：

BRAIN TUMOR PATHOLOGY | 2013年 / 30卷 / 01期

关键词：

Papillary tumor of the pineal region; Ependymal origin; Isocitrate dehydrogenase 1; Isocitrate dehydrogenase 2; Third ventricle; INHIBITING HORMONE SOMATOSTATIN; MUTATIONS;

D O I：

10.1007/s10014-012-0098-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations have been a focus area in glioma research as promising predictors. We report a case of PTPR that was characterized by local recurrence, although subtotal removal and radiotherapy seemed effective for many months. Histological examination showed ependymal features in the surgical specimens. As far as we are aware, this case study is the first to show that the IDH1/2 genotypes in PTPR cells are wild-type genotypes, which is consistent with the negative immunoreactivity that was observed for the IDH1 mutant antibody in this study.

引用

页码：45 / 49

页数：5

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