Emerging roles of lncRNAs in the post-transcriptional regulation in cancer

被引：195

作者：

He, Rong-Zhang ^{[1
,2
,3
,4
]}

Luo, Di-Xian ^{[2
]}

Mo, Yin-Yuan ^{[3
,4
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410078, Hunan, Peoples R China

[2] Chenzhou Univ South China, Collaborat Res Ctr Postdoctoral Mobile Stn, Natl & Local Joint Engn Lab High Mol Diag Technol, Translat Med Inst,Cent South Univ,Peoples Hosp 1, Chenzhou 432000, Peoples R China

[3] Univ Mississippi, Med Ctr, Dept Pharmacol Toxicol, Jackson, MS 39216 USA

[4] Univ Mississippi, Med Ctr, Canc Inst, Jackson, MS 39216 USA

来源：

GENES & DISEASES | 2019年 / 6卷 / 01期

关键词：

Alternative splicing; LncRNA; Posttranscriptional regulation; Protein stability; RNA binding proteins; RNA stability; LONG NONCODING RNA; RECEPTOR SPLICE VARIANT; PROSTATE-SPECIFIC GENE; KAPPA-B; CELL-GROWTH; EXPRESSION; TRANSCRIPTION; PROTEIN; GENOME; PHOSPHORYLATION;

D O I：

10.1016/j.gendis.2019.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master gene regulators at transcriptional and posttranscriptional levels, leading to tumorigenesis. In this review, we discuss latest developments in lncRNA-meditated gene expression at the post-transcriptional level, including gene splicing, mRNA stability, protein stability and nuclear trafficking. Copyright (C) 2019, Chongqing Medical University. Production and hosting by Elsevier B.V.

引用

页码：6 / 15

页数：10

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