Juvenile exposure to methylphenidate reduces cocaine reward and alters netrin-1 receptor expression in adulthood

被引：5

作者：

Argento, Jessica K. ^{[1
]}

Arvanitogiannis, Andreas ^{[2
]}

Flores, Cecilia ^{[1
]}

机构：

[1] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Montreal, PQ H4H 1R3, Canada

[2] Concordia Univ, Dept Psychol, Ctr Studies Behav Neurobiol, FRSQ Grp Rech Neurobiol Comportementale, Montreal, PQ H4B 1R6, Canada

来源：

BEHAVIOURAL BRAIN RESEARCH | 2012年 / 229卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

DCC; Ventral tegmental area; Conditioned place preference; Development; Guidance cues; Stimulant drugs; VENTRAL TEGMENTAL AREA; PROGRESSIVE RATIO SCHEDULE; DEFICIENT MICE; BEHAVIORAL SENSITIZATION; NUCLEUS-ACCUMBENS; ADOLESCENT EXPOSURE; LOCOMOTOR-ACTIVITY; DEPENDENT MANNER; DOPAMINE D-1; AMPHETAMINE;

D O I：

10.1016/j.bbr.2012.01.008

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The guidance cue netrin-1 acting on mesocorticolimbic dopamine (DA) neurons through its receptor DCC (deleted in colorectal cancer) has been implicated in the neuronal plasticity induced by psychostimulant drugs. We examined in C57/BL6 mice the effects of repeated juvenile methylphenidate (MPH) exposure on cocaine-reward sensitivity in adulthood and determined whether early MPH treatment alters adult expression of DCC in mesocorticolimbic DA regions. By using place conditioning, we show that adult mice exposed to MPH during the juvenile period are less sensitive to cocaine-reward compared to saline-controls. Furthermore, by means of immunoblotting, we demonstrate that early MPH treatment attenuates adult DCC expression in the ventral tegmental area (VTA) selectively. These results support previous evidence that developmental MPH treatment diminishes cocaine-reward in adulthood and are the first to suggest that DCC in the VTA may participate in this enduring effect. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：202 / 207

页数：6

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