Factors associated with the effectiveness of plasma exchange for the treatment of NMO-IgG-positive neuromyelitis optica spectrum disorders

被引：49

作者：

Lim, Young-Min ^{[1
]}

Pyun, So Young ^{[1
]}

Kang, Bong-Hui ^{[1
]}

Kim, Jimin ^{[1
]}

Kim, Kwang-Kuk ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul 138736, South Korea

来源：

MULTIPLE SCLEROSIS JOURNAL | 2013年 / 19卷 / 09期

关键词：

Plasma exchange; neuromyelitis optica spectrum disorders; prognostic factors; neuromyelitis optica-IgG; CNS DEMYELINATION; ATTACKS; PREDICTORS;

D O I：

10.1177/1352458512471875

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To identify factors associated with plasma exchange response in neuromyelitis optica (NMO) spectrum disorders, the clinical and magnetic resonance imaging (MRI) features of 31 NMO-IgG-positive patients receiving plasma exchange for steroid-resistant exacerbations were analyzed. Functional improvement was observed in 65% of the patients. A lower baseline Expanded Disability Status Scale score was associated with favorable response (p = 0.040). Patients without cord atrophy had a higher success rate than patients with atrophy (p = 0.016). Levels of NMO-IgG did not differ between responders and non-responders before and after plasma exchange. In conclusion, a minimal pre-existing disability is the primary determinant of the effectiveness of plasma exchange.

引用

页码：1216 / 1218

页数：3

共 11 条

[1] Plasma exchange in severe spinal attacks associated with neuromyelitis optica spectrum disorder [J].

Bonnan, M. ;

Valentino, R. ;

Olindo, S. ;

Mehdaoui, H. ;

Smadja, D. ;

Cabre, P. .

MULTIPLE SCLEROSIS JOURNAL, 2009, 15 (04) :487-492

[2] Plasma exchange for severe attacks of CNS demyelination: Predictors of response [J].

Keegan, M ;

Pineda, AA ;

McClelland, RL ;

Darby, CH ;

Rodriguez, M ;

Weinshenker, BG .

NEUROLOGY, 2002, 58 (01) :143-146

[3] A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis [J].

Lennon, VA ;

Wingerchuk, DM ;

Kryzer, TJ ;

Pittock, SJ ;

Lucchinetti, CF ;

Fujihara, K ;

Nakashima, I ;

Weinshenker, BG .

LANCET, 2004, 364 (9451) :2106-2112

[4] Plasma exchange for acute attacks of CNS demyelination Predictors of improvement at 6 months [J].

Llufriu, S. ;

Castillo, J. ;

Blanco, Y. ;

Ramio-Torrenta, L. ;

Rio, J. ;

Valles, M. ;

Lozano, M. ;

Castella, M. D. ;

Calabia, J. ;

Horga, A. ;

Graus, F. ;

Montalban, X. ;

Saiz, A. .

NEUROLOGY, 2009, 73 (12) :949-953

[5] Beneficial Plasma Exchange Response in Central Nervous System Inflammatory Demyelination [J].

Magana, Setty M. ;

Keegan, B. Mark ;

Weinshenker, Brian G. ;

Erickson, Bradley J. ;

Pittock, Sean J. ;

Lennon, Vanda A. ;

Rodriguez, Moses ;

Thomsen, Kristine ;

Weigand, Stephen ;

Mandrekar, Jay ;

Linbo, Linda ;

Lucchinetti, Claudia F. .

ARCHIVES OF NEUROLOGY, 2011, 68 (07) :870-878

[6] The rescue effect of plasma exchange for neuromyelitis optica [J].

Wang, Kai-Chen ;

Wang, Shuu-Jiun ;

Lee, Chao-Lin ;

Chen, Shao-Yuan ;

Tsai, Ching Piao .

JOURNAL OF CLINICAL NEUROSCIENCE, 2011, 18 (01) :43-46

[7] Therapeutic efficacy of plasma exchange in NMO-IgG-positive patients with neuromyelitis optica [J].

Watanabe, S. ;

Nakashima, I. ;

Misu, T. ;

Miyazawo, I. ;

Shiga, Y. ;

Fujihara, K. ;

Itoyama, Y. .

MULTIPLE SCLEROSIS JOURNAL, 2007, 13 (01) :128-132

[8]

Weinshenker BG, 1999, ANN NEUROL, V46, P878, DOI 10.1002/1531-8249(199912)46:6<878::AID-ANA10>3.0.CO

[9]

2-Q

[10] Revised diagnostic criteria for neuromyelitis optica [J].

Wingerchuk, D. M. ;

Lennon, V. A. ;

Pittock, S. J. ;

Lucchinetti, C. F. ;

Weinshenker, B. G. .

NEUROLOGY, 2006, 66 (10) :1485-1489

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