The Drosophila IMD pathway in the kactivation of the humoral immune response

被引：271

作者：

Kleino, Anni ^{[1
]}

Silverman, Neal ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis, Worcester, MA 01605 USA

来源：

DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2014年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Immune response; NF-kappa B signaling; Drosophila; NF-KAPPA-B; PEPTIDOGLYCAN RECOGNITION PROTEINS; ANTIMICROBIAL PEPTIDE GENES; GRAM-NEGATIVE INFECTION; DEATH DOMAIN PROTEIN; PGRP-LC; ANTIBACTERIAL DEFENSE; INDUCIBLE EXPRESSION; NUCLEAR RECEPTORS; STRUCTURAL BASIS;

D O I：

10.1016/j.dci.2013.05.014

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-kappa B signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：25 / 35

页数：11

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