Polarimetric imaging of uterine cervix: a case study

被引：222

作者：

Pierangelo, Angelo ^{[1
]}

Nazac, Andre ^{[2
]}

Benali, Abdelali ^{[3
]}

Validire, Pierre ^{[3
]}

Cohen, Henri ^{[4
]}

Novikova, Tatiana ^{[1
]}

Ibrahim, Bicher Haj ^{[1
]}

Manhas, Sandeep ^{[1
]}

Fallet, Clement ^{[1
]}

Antonelli, Maria-Rosaria ^{[1
]}

Antonello-De Martino ^{[1
]}

机构：

[1] Ecole Polytech, CNRS, LPICM, F-91128 Palaiseau, France

[2] CHU Bicetre, AP HP, Serv Gynecol Obstet, F-94275 Le Kremlin Bicetre, France

[3] Inst Mutualiste Montsouris, Dept Anat Pathol, F-75014 Paris, France

[4] Inst Mutualiste Montsouris, F-75014 Paris, France

来源：

OPTICS EXPRESS | 2013年 / 21卷 / 12期

关键词：

OPTICAL-DETECTION SYSTEM; INTRAEPITHELIAL NEOPLASIA; CANCER DETECTION; COLPOSCOPY; DIAGNOSIS; TISSUE; DECOMPOSITION; ACCURACY; LIGHT;

D O I：

10.1364/OE.21.014120

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a preliminary investigation of macroscopic polarimetric imaging of uterine cervix. Orthogonal state contrast (OSC) images of healthy and anomalous cervices have been taken in vivo at 550 nm. Four ex vivo cervix samples have been studied in full Muller polarimetry, at 550 nm and 700 nm, and characterized in detail by standard pathology. One sample was totally healthy, another one carried CIN lesions at very early stage (CIN1) in its visible exocervical region, while for the other two samples more advanced (CIN3) lesions were present, together with visible glandular epithelium (ectropion). Significant birefringence has been observed in the healthy regions of all six samples, both in vivo and ex vivo. Standard treatments of the Mueller images of the ex vivo samples allowed to quantify both retardation and depolarization. Retardation reached 60 in healthy regions, and disappeared in the anomalous regions of the other three ex vivo samples. The depolarization power was largest in healthy regions, and lower in CINs and ectropion. Possible origins of the observed effects are briefly discussed. (C) 2013 Optical Society of America

引用

页码：14120 / 14130

页数：11

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