Toward the next generation of NK cell-based adoptive cancer immunotherapy

被引：15

作者：

Ni, Jing ^{[1
]}

Miller, Matthias ^{[1
]}

Stojanovic, Ana ^{[1
]}

Cerwenka, Adelheid ^{[1
]}

机构：

[1] German Canc Res Ctr, Jr Res Grp Innate Immun, Heidelberg, Germany

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 04期

关键词：

cancer; CD4(+) T cells; immunotherapy; natural killer cells; radiation therapy; NATURAL-KILLER-CELLS;

D O I：

10.4161/onci.23811

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The adoptive transfer of interleukin (IL)-2-expanded natural killer (NK) cells has provided unsatisfactory clinical benefits to patients affected by solid tumors. Our study demonstrates that the activation of NK cells with IL-12/IL-15/IL-18 prior to transfer into tumor-bearing mice is critical for obtaining high recovery rates, effector functions in vivo and tumor regression.

引用

页数：3

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