Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer A case report and literature review

被引:45
作者
Chen, Jia-Hung [1 ]
Lee, Kang-Yun [2 ]
Hu, Chaur-Jong [1 ,3 ]
Chung, Chen-Chih [1 ,3 ]
机构
[1] Taipei Med Univ, Shuang Ho Hosp, Dept Neurol, 291 Zhongzheng Rd, New Taipei 23561, Taiwan
[2] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Pulm Med, New Taipei, Taiwan
[3] Taipei Med Univ, Sch Med, Dept Neurol, Taipei, Taiwan
关键词
checkpoint inhibitors; immune-related adverse events; myasthenia gravis; myositis; polyneuropathy; MELANOMA; THERAPY;
D O I
10.1097/MD.0000000000009262
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rationale: Immune checkpoint inhibitors have led to the development of new approaches for cancer treatment with positive outcomes. However, checkpoint blockade is associated with a unique spectrum of immune-related adverse events (irAEs), which may cause irreversible neurological deficits and even death. Patient concerns: We presented a case of a 57-year-old man with non-small-cell lung cancer. who developed ptosis, dyspnea, and muscle weakness as initial symptoms with progression after the treatment with ipilimumab and nivolumab. Diagnoses: Myasthenia gravis was confirmed by serum acetylcholine receptor antibody and single fiber electromyography. Myositis was identified by high level of serum creatine phosphokinase and electromyography. Polyneuropathy was identified by nerve conduction study. Interventions: The patient underwent treatment with steroid and pyridostigmine. Respiratory rehabilitation was also performed. Outcomes: Dyspnea and muscle weakness improved gradually. Ipilimumab and nivolumab were permanently discontinued. Lessons: This case has increased the clinical awareness by indicating that the checkpoint inhibitors-related neurological irAEs could be complicated and simultaneously involve multiple neurological systems. Early recognition and complete evaluation are critical in clinical practice.
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页数:4
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