Chitosan/polyethylene glycol diacrylate films as potential wound dressing material

被引：92
|
作者：
Zhang, Xiaodan [1 ]
Yang, Dongzhi [1 ]
Nie, Jun [1 ]
机构：
[1] Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2008年 / 43卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Chitosan; Polyethylene glycol diacrylate; Wound dressing material;
D O I：
10.1016/j.ijbiomac.2008.08.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Michael addition reaction of Chitosan (CS) and polyethylene glycol diacrylate (PEGDA) was carried out successfully in acidic solution. Films with CS/PEGDA weight ratios from 100/0 to 0/100 in 10% increments were analyzed by Fourier transform infrared (FTIR) spectroscopy, Scanning Electron Microscope (SEM) and X-Ray Diffraction (XRD). Additionally, the films were characterized by measuring mechanical property, swelling property. The potential application of the CS/PEGDA film as wound dressing material was evaluated in vitro by using mouse fibroblasts (L929) as reference cell lines, indirect cytotoxicity assessment indicated that CS/PEGDA films were nontoxic to L929 cell. (C) 2008 Published by Elsevier B.V.
引用
收藏
页码：456 / 462
页数：7
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