Leveraging Material Properties in Fluorescence Anion Sensor Arrays: A General Approach

被引:57
作者
Anzenbacher, Pavel, Jr. [1 ,2 ]
Liu, Yuanli [1 ,2 ]
Palacios, Manuel A. [1 ,2 ]
Minami, Tsuyoshi [1 ,2 ]
Wang, Zhuo [1 ,2 ]
Nishiyabu, Ryuhei [3 ]
机构
[1] Bowling Green State Univ, Dept Chem, Bowling Green, OH 43403 USA
[2] Bowling Green State Univ, Ctr Photochem Sci, Bowling Green, OH 43403 USA
[3] Tokyo Metropolitan Univ, Grad Sch Urban Environm Sci, Dept Appl Chem, Tokyo 1920397, Japan
基金
美国国家科学基金会;
关键词
anions; fluorescence; polymers; sensors; supramolecular chemistry; MOLECULARLY IMPRINTED POLYMERS; ION-SELECTIVE ELECTRODES; SUPRAMOLECULAR HYDROGEL; TRANSPORT-PROPERTIES; SIGNAL-TRANSDUCTION; RATIOMETRIC SENSOR; DUAL FLUORESCENCE; CHEMICAL SENSORS; RATIONAL DESIGN; WATER TRANSPORT;
D O I
10.1002/chem.201204188
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
As the demand for probes suitable for sensor development increases, investigation of approaches that utilize known successful receptors gains in general importance. This study describes a two-prong approach that can be used as a guide to developing sensors from known receptors. First, the conversion of a simple receptor, calix[4]pyrrole, into a fluorescent probe to establish a ratiometric signal is described. Secondly, the sensors that employ an output from a single ratiometric calix[4]pyrrole probe are fabricated by using poly(ether-urethane) hydrogel copolymers. These hydrogels are designed to absorb, internalize and transport aqueous electrolytes. A sensor array of ten different poly(ether-urethane) matrices with varying comonomer proportions were doped with a single probe and were exposed to eight different anions: acetate, benzoate, fluoride, chloride, phosphate, pyrophosphate, hydrogen sulfide, and cyanide, eight urine samples and anti-inflammatory drugs (NSAIDs). The poly(ether-urethane) matrices comprise different proportions of anion-binding urethane moieties and different hydrophilicity given by the ratio between ethylene glycol ether and butylene glycol ether. This diversity in the hydration behavior provides different environment polarity, in which the recognition and self-assembly processes display enough diverse behavior to allow for unique response of the probe to the analytes. Furthermore, a single probe is shown to recognize eight different aqueous anions and eight urine samples when embedded in ten different polyurethanes in an array that displays 100% classification accuracy. To demonstrate the potential of the concept for quantitative studies, an estimation of non-steroidal anti-inflammatory drugs ibuprofen and diclofenac in water and in saliva was performed. A limit of detection of 0.1ppm and a dynamic range of 0.1-0.6 and 0.05-60ppm was observed, respectively. Given the general difficulty of chemosensors to recognize aqueous anions, the fact that one probe recognizes eight different analytes attests to an enormous effect of the polymer environment on the recognition process. This method could be used to generate a variety of sensor arrays for various analyses including species that are difficult to recognize, such as small-molecule- and inorganic anions.
引用
收藏
页码:8497 / 8506
页数:10
相关论文
共 110 条
[1]   Sensing of aqueous phosphates by polymers with dual modes of signal transduction [J].
Aldakov, D ;
Anzenbacher, P .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (15) :4752-4753
[2]  
[Anonymous], 2004, OPTICAL SENSORS IND
[3]  
[Anonymous], 2001, ANGEW CHEM INT ED, V40, P3118
[4]  
[Anonymous], 1996, COMPREHENSIVE SUPRAM
[5]  
[Anonymous], 2007, ANGEW CHEM INT ED, V46, P7849
[6]  
[Anonymous], 1995, ANGEW CHEM INT ED EN, V33, P2363
[7]  
[Anonymous], 2006, ANGEW CHEM INT ED, V45, P5518
[8]   Supramolecular analytical chemistry [J].
Anslyn, Eric V. .
JOURNAL OF ORGANIC CHEMISTRY, 2007, 72 (03) :687-699
[9]   Trends in the design and application of optical chemosensors in pharmaceutical and biomedical analysis [J].
Antonia Martin, M. ;
Olives, Ana I. ;
del Castillo, Benito ;
Carlos Menendez, J. .
CURRENT PHARMACEUTICAL ANALYSIS, 2008, 4 (03) :106-117
[10]   Determination of NSAIDs in river sediment samples [J].
Antonic, Jan ;
Heath, Ester .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2007, 387 (04) :1337-1342