Nematode neuropeptide receptors and their development as anthelmintic screens

被引：17
作者：
Greenwood, K
Williams, T
Greary, T
机构：
[1] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England
[2] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ H9X 3V9, Canada
来源：
PARASITOLOGY | 2005年 / 131卷
关键词：
nematodes; anthelmintic; discovery; FMRFamide; G protein-coupled receptors;
D O I：
10.1017/S003118200500819X
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
This review addresses the potential use of neuropeptide receptors for the discovery of anthelmintic agents, and particularly for the identification of non-peptide ligands. It outlines which nematode neuropeptides are known and have been characterized, the published information on drug discovery around these targets, information about existing high- and low-throughput screening systems and finally the likely safety of neuropeptide mimetics.
引用
收藏
页码：S169 / S177
页数：9
相关论文
共 77 条
[41]   ENDOGENOUS OPIOID PEPTIDES - MULTIPLE AGONISTS AND RECEPTORS [J].
LORD, JAH ;
WATERFIELD, AA ;
HUGHES, J ;
KOSTERLITZ, HW .
NATURE, 1977, 267 (5611) :495-499
[42]  
Lowery DE, 2003, United States Patent, Patent No. [US 6632621 B1, 6632621]
[43]   BIOCHEMICAL-CHARACTERIZATION OF FMRF-NH2-LIKE PEPTIDES IN SPINAL CORDS OF VARIOUS MAMMALIAN-SPECIES USING SPECIFIC RADIOIMMUNOASSAYS [J].
MAJANE, EA ;
CASANOVA, MF ;
YANG, HYT .
PEPTIDES, 1988, 9 (05) :1137-1144
[44]   FMRF-NH2-LIKE MAMMALIAN OCTAPEPTIDE - POSSIBLE ROLE IN OPIATE DEPENDENCE AND ABSTINENCE [J].
MALIN, DH ;
LAKE, JR ;
HAMMOND, MV ;
FOWLER, DE ;
ROGILLIO, RB ;
BROWN, SL ;
SIMS, JL ;
LEECRAFT, BM ;
YANG, HYT .
PEPTIDES, 1990, 11 (05) :969-972
[45]   Isolation, pharmacology and gene organization of KPSFVRFamide:: A neuropeptide from Caenorhabditis elegans [J].
Marks, NJ ;
Maule, AG ;
Li, C ;
Nelson, LS ;
Thompson, DP ;
Alexander-Bowman, S ;
Geary, TG ;
Halton, DW ;
Verhaert, P ;
Shaw, C .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 254 (01) :222-230
[46]  
Marks NJ, 1997, PARASITOLOGY, V114, P531
[47]   Structural characterisation and pharmacology of KHEYLRFamide (AF2) and KSAYMRFamide (PF3/AF8) from Haemonchus contortus [J].
Marks, NJ ;
Sangster, NC ;
Maule, AG ;
Halton, DW ;
Thompson, DP ;
Geary, TG ;
Shaw, C .
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1999, 100 (02) :185-194
[48]   Inhibitory effects of nematode FMRFamide-related peptides (FaRPs) on muscle strips from Ascaris suum [J].
Maule, A. G. ;
Geary, T. G. ;
Bowman, J. W. ;
Marks, N. J. ;
Blair, K. L. ;
Halton, D. W. ;
Shaw, C. ;
Thompson, D. P. .
INVERTEBRATE NEUROSCIENCE, 1995, 1 (03) :255-265
[49]  
Maule Aaron G., 2002, Current Topics in Medicinal Chemistry, V2, P733, DOI 10.2174/1568026023393697
[50]   FMRFamide-related peptides (FaRPs) in nematodes: Occurrence and neuromuscular physiology [J].
Maule, AG ;
Bowman, JW ;
Thompson, DP ;
Marks, NJ ;
Friedman, AR ;
Geary, TG .
PARASITOLOGY, 1996, 113 :S119-S135
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