Nematode neuropeptide receptors and their development as anthelmintic screens

被引：17
作者：
Greenwood, K
Williams, T
Greary, T
机构：
[1] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England
[2] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ H9X 3V9, Canada
来源：
PARASITOLOGY | 2005年 / 131卷
关键词：
nematodes; anthelmintic; discovery; FMRFamide; G protein-coupled receptors;
D O I：
10.1017/S003118200500819X
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
This review addresses the potential use of neuropeptide receptors for the discovery of anthelmintic agents, and particularly for the identification of non-peptide ligands. It outlines which nematode neuropeptides are known and have been characterized, the published information on drug discovery around these targets, information about existing high- and low-throughput screening systems and finally the likely safety of neuropeptide mimetics.
引用
收藏
页码：S169 / S177
页数：9
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