Copper-Catalyzed Oxidative Diamination of Terminal Alkynes by Amidines: Synthesis of 1,2,4-Trisubstituted Imidazoles

被引：141
作者：
Li, Jihui [1 ]
Neuville, Luc [1 ]
机构：
[1] CNRS, Ctr Rech Gif, Inst Chim Subst Nat, Lab Int Associe, F-91198 Gif Sur Yvette, France
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 07期
关键词：
ONE-POT SYNTHESIS; N BOND FORMATION; FACILE SYNTHESIS; C-N; PALLADIUM; AMINATION; SPIROOXINDOLES; BENZIMIDAZOLES; COORDINATION; OXYGENATION;
D O I：
10.1021/ol400560m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient copper-catalyzed synthesis of 1,2,4-trisubstituted imidazoles using amidines and terminal alkynes has been developed. Overall, the oxidative process, which Involves Na2CO3, pyridine, a catalytic amount of CuCl2 center dot 2H(2)O, and oxygen (1 atm), consisted of a regioselective diamination of alkynes allowing the synthesis of diverse imidazoles in modest to good yields.
引用
收藏
页码：1752 / 1755
页数：4
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