Copper-Catalyzed Oxidative Diamination of Terminal Alkynes by Amidines: Synthesis of 1,2,4-Trisubstituted Imidazoles

被引：140

作者：

Li, Jihui ^{[1
]}

Neuville, Luc ^{[1
]}

机构：

[1] CNRS, Ctr Rech Gif, Inst Chim Subst Nat, Lab Int Associe, F-91198 Gif Sur Yvette, France

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 07期

关键词：

ONE-POT SYNTHESIS; N BOND FORMATION; FACILE SYNTHESIS; C-N; PALLADIUM; AMINATION; SPIROOXINDOLES; BENZIMIDAZOLES; COORDINATION; OXYGENATION;

D O I：

10.1021/ol400560m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient copper-catalyzed synthesis of 1,2,4-trisubstituted imidazoles using amidines and terminal alkynes has been developed. Overall, the oxidative process, which Involves Na2CO3, pyridine, a catalytic amount of CuCl2 center dot 2H(2)O, and oxygen (1 atm), consisted of a regioselective diamination of alkynes allowing the synthesis of diverse imidazoles in modest to good yields.

引用

页码：1752 / 1755

页数：4

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