Alcohol, Liver, Systemic Inflammation and Skin: A Focus on Patients with Psoriasis

被引：37

作者：

Farkas, A. ^{[1
]}

Kemeny, L. ^{[1
,2
,3
]}

机构：

[1] Univ Szeged, Dept Dermatol & Allergol, HU-6720 Szeged, Hungary

[2] Hungarian Acad Sci, Dermatol Res Grp, Szeged, Hungary

[3] Univ Szeged, HU-6720 Szeged, Hungary

来源：

SKIN PHARMACOLOGY AND PHYSIOLOGY | 2013年 / 26卷 / 03期

关键词：

Psoriasis; Alcohol; Acetaldehyde; Acetone; Alcoholic liver disease; Systemic inflammation; TUMOR-NECROSIS-FACTOR; PERIPHERAL-BLOOD MONOCYTES; FACTOR-ALPHA; BACTERIAL LIPOPOLYSACCHARIDE; INTERLEUKIN-6; CONCENTRATIONS; HUMAN KERATINOCYTES; OXIDATIVE STRESS; DISEASE; ETHANOL; HEPATITIS;

D O I：

10.1159/000348865

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Emerging evidence suggests that excessive alcohol consumption is associated with psoriasis. In alcoholics, antipsoriatic treatments are less efficient, but more toxic and an additional challenge is poor therapeutic compliance. There is a correlation between excess alcohol intake and increased risk of infections, but on the other hand alcohol and its metabolites can trigger a persistent systemic inflammation, mediated by pro-inflammatory cytokines released from activated Kupffer cells in the liver and from monocytes in the circulation. Ethanol and its metabolites can also enhance lymphocyte and keratinocyte activation and proliferation and can increase the mRNA levels of genes characteristic for proliferating keratinocytes. In this review, we discuss the mechanisms by which alcohol contributes to psoriasis development focusing on liver, systemic inflammation and skin. Copyright (c) 2013 S. Karger AG, Basel

引用

页码：119 / 126

页数：8

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