Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population

被引：7
|
作者：
Chen, Gui-Mei [1 ,2 ]
Feng, Chen-Chen [1 ,2 ]
Ye, Qian-Ling [3 ]
Wang, Juan [1 ,2 ]
Cen, Han [1 ,2 ]
Li, Rui [1 ,2 ]
Peng, Hui [1 ,2 ]
Zhou, Mo [1 ,2 ]
Leng, Rui-Xue [1 ,2 ]
Fan, Yin-Guang [1 ,2 ]
Tao, Jin-Hui [4 ]
Pan, Hai-Feng [1 ,2 ]
Ye, Dong-Qing [1 ,2 ]
机构：
[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China
[2] Anhui Prov Lab Populat Hlth & Major Dis Screening, Hefei 230032, Anhui, Peoples R China
[3] Anhui Med Univ, Dept Hematol, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China
[4] Anhui Prov Hosp, Dept Rheumatol & Immunol, Hefei 230001, Anhui, Peoples R China
来源：
INFLAMMATION RESEARCH | 2013年 / 62卷 / 08期
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
Systemic lupus erythematosus; IL-23R gene; Polymorphism; Chinese population; INTERLEUKIN; 23; RECEPTOR; REVISED CRITERIA; CONFER RISK; DISEASE; IL23R; CLASSIFICATION; VARIANTS; CYTOKINE; SHESIS; CELLS;
D O I：
10.1007/s00011-013-0636-x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The aim to this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin (IL)-23 receptor gene and systemic lupus erythematosus (SLE) in a Chinese population. A case-control study was performed to investigate the associations of SNPs in IL-23R gene (rs10889677 and rs1884444) with susceptibility to SLE in 521 Chinese SLE patients and 527 normal controls. The chi-square test and unconditional Logistic regression were used to analysis by SPSS 10.1 software. No significant differences were detected for the distribution of allele and genotype frequencies of these two SNPs between patients and controls as well as SLE patients with nephritis (LN) and those without nephritis. The findings suggest that the polymorphisms of IL-23R gene might not contribute to the susceptibility of SLE in the Chinese population.
引用
收藏
页码：791 / 795
页数：5
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