Genetic susceptibility and mechanisms for refractive error

被引：42
作者：
Stambolian, D. [1 ]
机构：
[1] Univ Penn, Dept Ophthalmol, Philadelphia, PA 19104 USA
来源：
CLINICAL GENETICS | 2013年 / 84卷 / 02期
关键词：
animal models; gene-environment interaction; genetic variation; hyperopia; myopia; refractive error; GENOME-WIDE ASSOCIATION; HIGH-GRADE MYOPIA; RISK-FACTORS; COMMON VARIANTS; RARE VARIANTS; PREVALENCE; LOCI; CHINESE; HSP90; PHENOTYPE;
D O I：
10.1111/cge.12180
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Refractive errors, myopia and hyperopia, are the most common causes of visual impairment worldwide. Recent advances in genetics have been utilized to identify a wealth of genetic loci believed to contain susceptibility genes for refractive error (RE). The current genetic evidence confirms that RE is influenced by both common and rare variants with a significant environmental component. These studies argue that only by combining genetic and environmental knowledge with in vivo measurements of biological states will it be possible to understand the underlying biology of RE that will lead to novel therapeutic targets and accurate genetic predictions.
引用
收藏
页码：102 / 108
页数：7
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