Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi

被引：29

作者：

Sun, Xianhua ^{[1
]}

Su, Xiaoyun ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Key Lab Feed Biotechnol, Minist Agr, Feed Res Inst, 12 South Zhongguancun St, Beijing 100081, Peoples R China

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2019年 / 35卷 / 04期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Filamentous fungi; Secretion pathway; Trichoderma reesei; Aspergilli; Genetic engineering; Heterologous expression; GTP-BINDING PROTEIN; TRICHODERMA-REESEI; ASPERGILLUS-NIGER; ENDOPLASMIC-RETICULUM; CELLULASE PRODUCTION; DISULFIDE-ISOMERASE; SIGNAL PEPTIDE; MESSENGER-RNA; BREFELDIN-A; KINASE COT1;

D O I：

10.1007/s11274-019-2630-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Filamentous fungi are important microorganisms used in industrial production of proteins and enzymes. Among these organisms, Trichoderma reesei, Aspergilli, and more recently Myceliophthora thermophile are the most widely used and promising ones which have powerful protein secretion capability. In recent years, there have been tremendous achievements in understanding the molecular mechanisms of the secretory pathways in filamentous fungi. The acquired pieces of knowledge can be harnessed to enhance protein production in filamentous fungi with assistance of state-of-the-art genetic engineering techniques.

引用

页数：10

共 95 条

[1] The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production [J].

Aerts, David ;

Hauer, Esther E. ;

Ohm, Robin A. ;

Arentshorst, Mark ;

Teertstra, Wieke R. ;

Phippen, Christopher ;

Ram, Arthur F. J. ;

Frisvad, Jens C. ;

Wosten, Han A. B. .

ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2018, 111 (03) :311-322

[2] Effect of culture medium composition on Trichoderma reesei's morphology and cellulase production [J].

Ahamed, Aftab ;

Vermette, Patrick .

BIORESOURCE TECHNOLOGY, 2009, 100 (23) :5979-5987

[3] The polarisome component SPA-2 localizes at the apex of Neurospora crassa and partially colocalizes with the Spitzenkorper [J].

Araujo-Palomares, Cynthia L. ;

Riquelme, Meritxell ;

Castro-Longoria, Ernestina .

FUNGAL GENETICS AND BIOLOGY, 2009, 46 (08) :551-563

[4] THE GTP-BINDING PROTEIN YPT1 IS REQUIRED FOR TRANSPORT INVITRO - THE GOLGI-APPARATUS IS DEFECTIVE IN YPT1 MUTANTS [J].

BACON, RA ;

SALMINEN, A ;

RUOHOLA, H ;

NOVICK, P ;

FERRONOVICK, S .

JOURNAL OF CELL BIOLOGY, 1989, 109 (03) :1015-1022

[5] THE DEVELOPMENT OF ASPERGILLUS-NIGER VAR AWAMORI AS A HOST FOR THE EXPRESSION AND SECRETION OF HETEROLOGOUS GENE-PRODUCTS [J].

BERKA, RM ;

KODAMA, KH ;

REY, MW ;

WILSON, LJ ;

WARD, M .

BIOCHEMICAL SOCIETY TRANSACTIONS, 1991, 19 (03) :681-685

[6] ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER [J].

Bernasconi, Riccardo ;

Molinari, Maurizio .

CURRENT OPINION IN CELL BIOLOGY, 2011, 23 (02) :176-183

[7] Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger [J].

Carvalho, Neuza D. S. P. ;

Arentshorst, Mark ;

Kooistra, Rolf ;

Stam, Hein ;

Sagt, Cees M. ;

van den Hondel, Cees A. M. J. J. ;

Ram, Arthur F. J. .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2011, 89 (02) :357-373

[8] HIGH-LEVEL EXPRESSION OF RECOMBINANT GENES IN ASPERGILLUS-ORYZAE [J].

CHRISTENSEN, T ;

WOELDIKE, H ;

BOEL, E ;

MORTENSEN, SB ;

HJORTSHOEJ, K ;

THIM, L ;

HANSEN, MT .

BIO-TECHNOLOGY, 1988, 6 (12) :1419-1422

[9] Protein transport: The nonclassical ins and outs [J].

Cleves, AE .

CURRENT BIOLOGY, 1997, 7 (05) :R318-R320

[10] The secretion pathway in filamentous fungi: A biotechnological view [J].

Conesa, A ;

Punt, PJ ;

van Luijk, N ;

van den Hondel, CAMJJ .

FUNGAL GENETICS AND BIOLOGY, 2001, 33 (03) :155-171

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