One-Pot Synthesis of Pyrrolo[3,4-a]indolizine-1,3-diones through [3+2] Cycloaddition-Oxidation Reaction Catalyzed by CuII Salt and O2 as the Oxidant

被引：18

作者：

Liu, Yun ^{[1
,2
]}

Hu, Hua-You ^{[3
]}

Su, Xian-Bin ^{[4
]}

Sun, Jin-Wei ^{[1
,2
]}

Cao, Chang-Sheng ^{[1
,2
]}

Shi, Yan-Hui ^{[1
,2
]}

机构：

[1] Jiangsu Normal Univ, Dept Chem & Chem Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Jiangsu Normal Univ, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

[3] Huaiyin Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Jiangsu, Peoples R China

[4] Nanjing Univ Technol, Dept Chem & Chem Engn, Nanjing 211816, Jiangsu, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 2013卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Synthetic methods; Homogeneous catalysis; Copper; Cycloaddition; Oxidation; Nitrogen heterocycles; HETEROAROMATIC N-YLIDES; INDOLIZINE DERIVATIVES; IN-VIVO; INHIBITORS; CASTANOSPERMINE; ANALOGS; MICE;

D O I：

10.1002/ejoc.201201488

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot synthesis of pyrrolo[3,4-a]indolizine-1,3-diones has been developed from maleimides, pyridines, and acyl bromides through a [3+2] cyclization-oxidation reaction catalyzed by Cu-II salt under O-2 atmosphere. The advantage of this method is the use of molecular oxygen as the oxidant, in the presence of a catalytic amount of hydrated copper(II) chloride, to accomplish the reaction with broad substrate scope and excellent yields.

引用

页码：2020 / 2026

页数：7

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