Synthesis and characterization of membranes obtained by graft copolymerization of 2-hydroxyethyl methacrylate and acrylic acid onto chitosan

被引：84
作者：
dos Santos, KSCR
Coelho, JFJ
Ferreira, P
Pinto, I
Lorenzetti, SG
Ferreira, EI
Higa, OZ
Gil, MH
机构：
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05508900 Sao Paulo, Brazil
[2] Univ Coimbra, Fac Ciencias & Tecnol, Dept Engn Quim, P-3030290 Coimbra, Portugal
[3] CNEN, IPEN, BR-05508900 Sao Paulo, Brazil
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2006年 / 310卷 / 1-2期
关键词：
chitosan; acrylic acid; 2-hydroxyethyl methacrylate; membranes; wound healing;
D O I：
10.1016/j.ijpharm.2005.11.019
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thrombogenicity and haemolytic activity of these membranes were evaluated. Chitosan-graft-AA-graft-HEMA showed to be the best matrix for drug delivery systems than chitosan-graft-AA because it retains good swelling properties, but the content in HEMA has improved cytocompatibility, hernocompatibility and thrombogenic character. (C) 2005 Elsevier B.V. All rights reserved.
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页码：37 / 45
页数：9
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