Photon-counting Detector CT: System Design and Clinical Applications of an Emerging Technology

被引:385
作者
Leng, Shuai [1 ]
Bruesewitz, Michael [1 ]
Tao, Shengzhen [1 ]
Rajendran, Kishore [1 ]
Halaweish, Ahmed F. [2 ]
Campeau, Norbert G. [1 ]
Fletcher, Joel G. [1 ]
McCollough, Cynthia H. [1 ]
机构
[1] Mayo Clin, Dept Radiol, 200 First St SW, Rochester, MN 55905 USA
[2] Siemens Healthcare, Malvern, PA USA
基金
美国国家卫生研究院;
关键词
SILICON-STRIP DETECTOR; COMPUTED-TOMOGRAPHY; SPECTRAL CT; IMAGE-RECONSTRUCTION; NOISE-REDUCTION; EXPERIMENTAL FEASIBILITY; PERFORMANCE; DECOMPOSITION; RESOLUTION; IODINE;
D O I
10.1148/rg.2019180115
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Photon-counting detector (PCD) CT is an emerging technology that has shown tremendous progress in the last decade. Various types of PCD CT systems have been developed to investigate the benefits of this technology, which include reduced electronic noise, increased contrast-to-noise ratio with iodinated contrast material and radiation dose efficiency, reduced beam-hardening and metal artifacts, extremely high spatial resolution (33 line pairs per centimeter), simultaneous multienergy data acquisition, and the ability to image with and differentiate among multiple CT contrast agents. PCD technology is described and compared with conventional CT detector technology. With the use of a whole-body research PCD CT system as an example, PCD technology and its use for in vivo high-spatial-resolution multienergy CT imaging is discussed. The potential clinical applications, diagnostic benefits, and challenges associated with this technology are then discussed, and examples with phantom, animal, and patient studies are provided. (C) RSNA, 2019
引用
收藏
页码:729 / 743
页数:15
相关论文
共 78 条
[1]   MARS spectral molecular imaging of lamb tissue: data collection and image analysis [J].
Aamir, R. ;
Chernoglazov, A. ;
Bateman, C. J. ;
Butler, A. P. H. ;
Butler, P. H. ;
Anderson, N. G. ;
Bell, S. T. ;
Panta, R. K. ;
Healy, J. L. ;
Mohr, J. L. ;
Rajendran, K. ;
Walsh, M. F. ;
de Ruiter, N. ;
Gieseg, S. P. ;
Woodfield, T. ;
Renaud, P. F. ;
Brooke, L. ;
Abdul-Majid, S. ;
Clyne, M. ;
Glendenning, R. ;
Bones, P. J. ;
Billinghurst, M. ;
Bartneck, C. ;
Mandalika, H. ;
Grasset, R. ;
Schleich, N. ;
Scott, N. ;
Nik, S. J. ;
Opie, A. ;
Janmale, T. ;
Tang, D. N. ;
Kim, D. ;
Doesburg, R. M. ;
Zainon, R. ;
Ronaldson, J. P. ;
Cook, N. J. ;
Smithies, D. J. ;
Hodge, K. .
JOURNAL OF INSTRUMENTATION, 2014, 9
[2]   Spectroscopic (multi-energy) CT distinguishes iodine and barium contrast material in MICE [J].
Anderson, N. G. ;
Butler, A. P. ;
Scott, N. J. A. ;
Cook, N. J. ;
Butzer, J. S. ;
Schleich, N. ;
Firsching, M. ;
Grasset, R. ;
de Ruiter, N. ;
Campbell, M. ;
Butler, P. H. .
EUROPEAN RADIOLOGY, 2010, 20 (09) :2126-2134
[3]  
Annapragada Ananth V, 2012, Methodist Debakey Cardiovasc J, V8, P18
[4]  
Badea CT, 2018, P SOC PHOTO-OPT INS, V10573
[5]   An algorithm for constrained one-step inversion of spectral CT data [J].
Barber, Rina Foygel ;
Sidky, Emil Y. ;
Schmidt, Taly Gilat ;
Pan, Xiaochuan .
PHYSICS IN MEDICINE AND BIOLOGY, 2016, 61 (10) :3784-3818
[6]   Hybrid Spectral Micro-CT: System Design, Implementation, and Preliminary Results [J].
Bennett, James R. ;
Opie, Alex M. T. ;
Xu, Qiong ;
Yu, Hengyong ;
Walsh, Michael ;
Butler, Anthony ;
Butler, Phillip ;
Cao, Guohua ;
Mohs, Aaron ;
Wang, Ge .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2014, 61 (02) :246-253
[7]   Photon-counting spectral computed tomography using silicon strip detectors: a feasibility study [J].
Bornefalk, Hans ;
Danielsson, Mats .
PHYSICS IN MEDICINE AND BIOLOGY, 2010, 55 (07) :1999-2022
[8]   A full-spectral Bayesian reconstruction approach based on the material decomposition model applied in dual-energy computed tomography [J].
Cai, C. ;
Rodet, T. ;
Legoupil, S. ;
Mohammad-Djafari, A. .
MEDICAL PHYSICS, 2013, 40 (11)
[9]   Three dimensional mapping of strontium in bone by dual energy K-edge subtraction imaging [J].
Cooper, D. M. L. ;
Chapman, L. D. ;
Carter, Y. ;
Wu, Y. ;
Panahifar, A. ;
Britz, H. M. ;
Bewer, B. ;
Zhouping, W. ;
Duke, M. J. M. ;
Doschak, M. .
PHYSICS IN MEDICINE AND BIOLOGY, 2012, 57 (18) :5777-5786
[10]   Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner [J].
Cormode, David P. ;
Si-Mohamed, Salim ;
Bar-Ness, Daniel ;
Sigovan, Monica ;
Naha, Pratap C. ;
Balegamire, Joelle ;
Lavenne, Franck ;
Coulon, Philippe ;
Roessl, Ewald ;
Bartels, Matthias ;
Rokni, Michal ;
Blevis, Ira ;
Boussel, Loic ;
Douek, Philippe .
SCIENTIFIC REPORTS, 2017, 7