Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

被引：104
|
作者：
Farache, Julia [1 ]
Zigmond, Ehud [1 ,2 ,3 ]
Shakhar, Guy [1 ]
Jung, Steffen [1 ]
机构：
[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel
[2] Tel Aviv Univ, Sourasky Med Ctr, Res Ctr Digest Tract & Liver Dis, IL-69978 Tel Aviv, Israel
[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2013年 / 91卷 / 03期
关键词：
intestine; macrophages; dendritic cells; homeostasis; inflammation; REGULATORY T-CELLS; LAMINA-PROPRIA; RETINOIC-ACID; EPITHELIAL-CELLS; ULCERATIVE-COLITIS; LY6C(HI) MONOCYTES; GUT; DIFFERENTIATION; EXPRESSION; MUCOSAL;
D O I：
10.1038/icb.2012.79
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103(+) dendritic cells and CX3CR1(+) macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD). Immunology and Cell Biology (2013) 91, 232-239; doi:10.1038/icb.2012.79; published online 12 February 2013
引用
收藏
页码：232 / 239
页数：8
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